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首页> 外文期刊>Journal of psychiatric research >Emotional eating in adolescents: a gene (SLC6A4/5-HTT) - depressive feelings interaction analysis.
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Emotional eating in adolescents: a gene (SLC6A4/5-HTT) - depressive feelings interaction analysis.

机译：青少年的情绪饮食：一个基因（SLC6A4 / 5-HTT）-抑郁感相互作用分析。

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Eating in response to distress--i.e. emotional eating--is highly prevalent in (female) adults with binge eating, but has only a very low prevalence in young children. The present study addresses the emergence of emotional eating in adolescence in relation to depressive feelings. Because a reduction of food intake is considered the biologically natural response to distress, we tested whether the a-typical stress-response of emotional eating develops in interaction with genetic vulnerability. We hypothesized that the short allele of the 5-HTTLPR polymorphism in the serotonin transporter gene, which is associated with lower serotonin activity, would moderate the relation between depressive feelings and the increase in emotional eating, particularly in females. A sample of Dutch families with two adolescents was included in a longitudinal study with a four-year follow-up. A moderator effect of 5-HTTLPR genotype on the relation between depressive feelings and the increase in emotional eating was found in both sexes in the youngest siblings (n = 286). In the older siblings (n = 298), this specific moderator effect was only found in the girls. Younger adolescents and older adolescent girls showed a higher increase in emotional eating if they carried the 5-HTTLPR short allele. This is the first study that found support for a gene x depressive feelings interaction on emergence of emotional eating in (female) adolescents.
机译：因遇难而进食-情感饮食-在（暴饮暴食）成年女性中非常普遍，但在幼儿中患病率很低。本研究解决了与抑郁情绪有关的青春期情绪饮食的出现。因为减少食物摄入被认为是对苦难的生物学自然反应，所以我们测试了情感进食的非典型应激反应是否与遗传易感性有关。我们假设5-羟色胺转运蛋白基因中5-HTTLPR多态性的短等位基因与较低的5-羟色胺活性有关，将缓解抑郁感与情绪饮食增加之间的关系，尤其是女性。在一项为期四年的随访的纵向研究中，包括了一个有两个青少年的荷兰家庭的样本。在最小的兄弟姐妹中，男女均发现了5-HTTLPR基因型对抑郁感和情绪饮食增加之间关系的调节作用（n = 286）。在年长的兄弟姐妹（n = 298）中，这种特定的调节作用仅在女孩中发现。如果携带5-HTTLPR短等位基因，则年轻的青少年和年长的青少年女孩的情绪饮食增加更多。这是第一项发现（女性）青少年在情绪饮食出现时支持基因x抑郁感相互作用的研究。

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