...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of psychiatric practice. >Clinical outcomes and low-dose levocarnitine supplementation in psychiatric inpatients with documented hypocarnitinemia: a retrospective chart review.
【24h】

Clinical outcomes and low-dose levocarnitine supplementation in psychiatric inpatients with documented hypocarnitinemia: a retrospective chart review.

机译：记录性低肉碱血症的精神病患者的临床结局和小剂量左卡尼汀补充：回顾性图表回顾。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Metabolic encephalopathy is one of the crucial manifestations of carnitine deficiency. In psychiatric patients, low serum carnitine levels may result from chronic valproate therapy. Despite the widespread use of valproate in psychiatry, neither carnitine deficiency nor supplementation has been studied in a psychiatric population. OBJECTIVE: To describe clinical outcomes in hospitalized psychiatric patients with documented hypocarnitinemia who were receiving oral levocarnitine supplementation. METHOD: Retrospective chart review. RESULTS: In 38 patients with hypocarnitinemia, a low-dose oral levocarnitine supplementation, in association with comprehensive psychiatric therapy, did not result in any adverse psychiatric or medical outcomes, and was associated with overall improved behavioral, cognitive, and motor functioning. Initially all patients had some degree of cognitive impairment, but after correction of carnitine serum levels, scores on the Mini-Mental State Examination (MMSE) improved in most of the patients (mean improvement 5.5 points, P <0.0001), and normalized in 11 cases. This allowed a correction of the diagnosis in 8 of 14 patients who had initially been diagnosed with dementia. African-American patients achieved significantly lower serum carnitine levels and MMSE scores than Caucasian patients with comparable therapy. CONCLUSION: We hypothesize that correction of carnitine depletion, either by levocarnitine supplementation or by valproate dose reduction, may enhance recovery from hypocarnitinemia-associated encephalopathy in psychiatric patients. Our findings also suggest that ethnic traits may affect carnitine bioavailability as well as cognitive outcomes in this clinical context. Further studies of carnitine metabolism and supplementation in psychiatric patients are warranted.
机译：背景：代谢性脑病是肉碱缺乏的重要表现之一。在精神病患者中，慢性丙戊酸盐治疗可能导致血清肉碱水平较低。尽管丙戊酸在精神病学中得到广泛使用，但尚未在精神病学人群中研究肉碱缺乏或补充。目的：描述接受口服左卡尼汀补充治疗的住院低卡尼汀血症的精神病患者的临床结局。方法：回顾性图表审查。结果：在38例低卡尼汀血症患者中，低剂量口服左卡尼汀补充剂与全面的精神科治疗相关联，不会导致任何精神或医学方面的不良后果，并且与行为，认知和运动功能的总体改善有关。最初，所有患者都有一定程度的认知障碍，但是在纠正肉碱血清水平后，大多数患者的小精神状态检查（MMSE）得分有所改善（平均改善5.5分，P <0.0001），并且在11位患者中标准化案件。这使得最初诊断为痴呆症的14位患者中的8位得以更正。非裔美国人患者的血清肉碱水平和MMSE评分明显低于接受类似治疗的白人患者。结论：我们假设通过补充左卡尼汀或减少丙戊酸剂量来纠正肉碱消耗，可以增强精神病患者低卡尼汀血症相关性脑病的恢复。我们的发现还表明，在这种临床情况下，种族特征可能会影响肉碱的生物利用度以及认知结果。有必要对精神病患者的肉毒碱代谢和补充进行进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号