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首页> 外文期刊>Journal of psychiatric practice. >Comparison of the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in depressed versus nondepressed patients.
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Comparison of the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in depressed versus nondepressed patients.

机译：抑郁症患者和非抑郁症患者中亚甲基四氢叶酸还原酶（MTHFR）C677T多态性的频率比较。

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Numerous studies have found an association between low serum folate levels and incidence of depression. Folic acid supplementation has been successfully used as an adjunct to treat depression in these patients. However, some individuals have a genetic deficiency in the methylene tetrahydrofolate reductase (MTHFR) gene that limits conversion of folic acid to its biologically active form, L-methylfolate. Several studies have identified a higher frequency of genetic variations in the MTHFR gene in depressed patients than in nondepressed controls. This study evaluated the frequency of the most common genetic variation MTHFR C667T in a group of depressed U.S. Caucasians and compared results with those of a control group of nondepressed U.S. Caucasians. Subjects were recruited from a psychiatric practice, an ambulatory care clinic, and the community. Informed consent and a cheek swab sample were obtained from each subject for analysis using real-time polymerase chain reaction (PCR). Allele and genotype frequencies were compared using Pearson X2 analysis. Complete data were obtained for 156 subjects. No significant differences were found in frequency of the MTHFR C667T T allele (0.415 vs 0.365; p=0.408) or the MTHFR C667T TT genotype (20.7% vs 17.6%; p=0.619) between the depressed and non-depressed controls, respectively. Therefore, use of L-methylfolate without an additional indication of need does not appear to be warranted in this group of U.S. Caucasians. Some patients may benefit from L-methylfolate, but an evidence-based approach, such as MTHFR genotyping, should be used to identify these specific patients. Additional research is also needed to confirm the benefit of L-methylfolate in specific patient populations (e.g., MTHFR TT genotype).
机译：许多研究发现血清叶酸水平低与抑郁症的发生之间存在关联。叶酸补充剂已成功地用作治疗这些患者抑郁的辅助剂。但是，有些人的四氢叶酸亚甲基还原酶（MTHFR）基因存在遗传缺陷，限制了叶酸向其生物活性形式L-甲基叶酸的转化。几项研究已经发现，抑郁症患者的MTHFR基因遗传变异的频率要高于非抑郁症患者。这项研究评估了一组抑郁的美国高加索人最常见的遗传变异MTHFR C667T的频率，并将结果与​​对照组的非抑郁的美国高加索人进行了比较。从精神科诊所，门诊诊所和社区招募受试者。从每个受试者获得知情同意书和脸颊拭子样品，以使用实时聚合酶链反应（PCR）进行分析。使用Pearson X2分析比较了等位基因和基因型频率。获得了156位受试者的完整数据。抑郁和非抑郁对照之间的MTHFR C667T T等位基因频率（0.415 vs 0.365; p = 0.408）或MTHFR C667T TT基因型频率（20.7％vs 17.6％; p = 0.619）均无明显差异。因此，在这组美国高加索人中似乎没有必要使用L-甲基叶酸而没有其他需要的迹象。一些患者可能会从L-甲基叶酸中受益，但是应该使用基于证据的方法（例如MTHFR基因分型）来识别这些特定患者。还需要进一步的研究来证实L-甲基叶酸在特定患者人群中的益处（例如MTHFR TT基因型）。

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