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首页> 外文期刊>Journal of psychiatric research >Activation of the cholinergic anti-inflammatory system in peripheral blood mononuclear cells from patients with Borderline Personality Disorder
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Activation of the cholinergic anti-inflammatory system in peripheral blood mononuclear cells from patients with Borderline Personality Disorder

机译：边缘性人格障碍患者外周血单个核细胞中胆碱能抗炎系统的激活

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A case-control study including patients (n = 20) with Borderline Personality Disorder (BPD) and healthy controls (n = 33) was carried out. To avoid interferences of other clinical conditions on biological findings, patients were free of current major depressive episodes or substance dependence disorders, and had no life history of schizophrenia, bipolar or neuropsychiatric disorders. Patients were free of medication for at least two weeks at the time of the study. Studies carried out in peripheral mononuclear blood cells and plasma evidence a systemic inflammatory condition in unstable-impulsive BPD patients. Specifically, a significant increase in some intracellular components of two main pro-inflammatory pathways such as iNOS and COX-2, as well as an increase in the plasma levels of the inflammatory cytokine IL1β. Interestingly, patients have an increase in the protein expression of the anti-inflammatory subtype of nicotinic receptor α7nAChR. This finding may reflect a possible mechanism trying to maintain intracellular inflammation pathways under control. All together, these results describe an imbalanced, pro-inflammatory and oxidant phenotype in BPD patients independent of plasma cotinine levels. Although more scientific evidence is needed, the determination of multiple components of pro- and anti-inflammatory cellular pathways have interesting potential as biological markers for BPD and other generalized impulsive syndromes, specially data obtained with α7nAChR and its lack of correlation with plasma levels of nicotine metabolites. Their pharmacological modulation with receptor modulators can be a promising therapeutic target to take into account in mental health conditions associated with inflammatory or oxidoitrosative consequences. Also, identifying at-risk individuals would be of importance for early detection and intervention in adolescent subjects before they present severe behavioural problems.
机译：进行了一项病例对照研究，其中包括边缘性人格障碍（BPD）的患者（n = 20）和健康对照（n = 33）。为避免其他临床状况对生物学结果的干扰，患者应避免出现当前的严重抑郁发作或物质依赖障碍，并且没有精神分裂症，双相情感障碍或神经精神疾病的生活史。在研究时，患者至少有两周没有药物治疗。在外周单核血细胞和血浆中进行的研究表明，不稳定冲动性BPD患者存在全身性炎症。具体而言，两个主要促炎途径（如iNOS和COX-2）的某些细胞内成分显着增加，以及炎性细胞因子IL1β的血浆水平增加。有趣的是，患者烟碱样受体α7nAChR的抗炎亚型的蛋白质表达增加。这一发现可能反映了试图将细胞内炎症途径维持在受控状态的可能机制。总之，这些结果描述了BPD患者的血浆不平衡水平，促炎和氧化剂表型，与血浆可替宁水平无关。尽管需要更多的科学证据，但确定促炎和抗炎细胞途径的多种成分具有作为BPD和其他普遍性冲动综合征的生物标记物的有趣潜力，特别是使用α7nAChR获得的数据及其与尼古丁血浆水平缺乏相关性代谢产物。考虑到与炎症或氧化/亚硝基作用有关的精神健康状况，用受体调节剂的药理学调节可以成为有前途的治疗目标。同样，在处于严重行为问题之前，识别高风险个体对于青少年受试者的早期发现和干预也很重要。

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