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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Peripheral accumulation of newly produced T and B lymphocytes in natalizumab-treated multiple sclerosis patients
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Peripheral accumulation of newly produced T and B lymphocytes in natalizumab-treated multiple sclerosis patients

机译：那他珠单抗治疗的多发性硬化症患者中新产生的T和B淋巴细胞的周围积累

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摘要

The anti-α4 monoclonal antibody natalizumab inhibits lymphocyte extravasation into the central nervous system and increases peripheral T and B lymphocytes in multiple sclerosis patients. To investigate whether the lymphocyte accumulation was due to a higher lymphocyte production, an altered homeostasis, or a differential transmigration of lymphocyte subsets through endothelia, T-cell receptor excision circles and kappa-deleting recombination excision circles were quantified before and after treatment, T-cell receptor repertoire was analyzed by spectratyping, and T- and B-lymphocyte subset migration was studied using transwell coated with vascular and lymphatic endothelial cells. We found that the number of newly produced T and B lymphocytes is increased because of a high release and of a low propensity of na?ve subsets to migrate across endothelial cells. In some patients this resulted in an enlargement of T-cell heterogeneity. Because new lymphocyte production ensures the integrity of immune surveillance, its quantification could be used to monitor natalizumab therapy safety.
机译：抗α4单克隆抗体那他珠单抗抑制多发性硬化症患者的淋巴细胞渗入中枢神经系统并增加外周T和B淋巴细胞。为了研究淋巴细胞积累是否是由于较高的淋巴细胞产生，稳态改变或淋巴细胞亚群通过内皮，T细胞受体切除环和κ缺失重组切除环的差异性迁移造成的，在治疗前后，对T-通过光谱分型分析细胞受体组成，并使用涂有血管和淋巴管内皮细胞的transwell研究T和B淋巴细胞亚群的迁移。我们发现新产生的T和B淋巴细胞的数量增加了，因为幼稚子集的高释放和低倾向性使其可以跨内皮细胞迁移。在某些患者中，这导致T细胞异质性增大。由于新产生的淋巴细胞可确保免疫监视的完整性，因此其定量可用于监视那他珠单抗治疗的安全性。

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