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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE
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IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE

机译：IgM自身抗体与独特的凋亡相关抗原相关，与SLE患者免受心血管事件和肾脏疾病的侵袭有关

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Emerging evidence suggests that there are IgM-autoantibodies that may play protective roles in SLE. While IgM are often considered polyreactive, we postulate that there are distinct sets of IgM-autoantibodies of defined autoreactive specificities relevant to different features of SLE. We examined the relationships between levels of IgM natural autoantibodies (NAbs) to apoptosis-associated phosphorylcholine (PC) or malondialdehyde (MDA) antigens, with lupus-associated autoantibodies and features of disease, in 120 SLE patients. IgM anti-PC was significantly higher in patients with low disease activity and less organ damage determined by the SELENA-SLEDAI, the physician's evaluation and the SLICC damage score. Furthermore, IgM anti-PC was significantly higher in patients without cardiovascular events. In contrast, IgM anti-cardiolipin and IgM anti-dsDNA were significantly higher in patients without renal disease. These results support the hypothesis that some IgM autoantibodies are part of a natural immune repertoire that provide homeostatic functions and protection from certain clinical lupus features.
机译：新兴证据表明，有一些IgM自身抗体可能在SLE中起保护作用。尽管IgM通常被认为是多反应性的，但我们假设存在与SLE的不同特征相关的不同IgM自身抗体定义的自身反应特异性。我们检查了120名SLE患者中IgM天然自身抗体（NAbs）与凋亡相关的磷酸胆碱（PC）或丙二醛（MDA）抗原，狼疮相关自身抗体与疾病特征之间的关系。根据SELENA-SLEDAI，医生的评估和SLICC损伤评分确定，在疾病活动低且器官损伤较少的患者中，IgM抗PC明显更高。此外，在无心血管事件的患者中，IgM抗PC明显更高。相反，在没有肾脏疾病的患者中，IgM抗心磷脂和IgM抗dsDNA明显更高。这些结果支持以下假设：某些IgM自身抗体是天然免疫库的一部分，可提供体内稳态功能并保护某些临床狼疮功能。

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