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On the armament and appearances of human myeloid-derived suppressor cells

机译:关于人类髓样抑制细胞的装备和外观

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摘要

Myeloid-derived suppressor cells (MDSC) have frequently been observed in patients with cancer. This heterogeneous population of myeloid cells can exert potent suppression of lymphocyte function and thereby poses a significant hurdle to natural or therapeutically induced anti-tumor immunity. On the other hand, the natural function of MDSC is not yet well understood and their role in infection, inflammation and autoimmune disease is still puzzling.Understanding MDSC biology will provide the tools necessary for therapeutic targeting of this population, but also permit exploitation of their strong tolerogenic function in the treatment of inflammatory conditions and the prevention of graft rejection.
机译:在癌症患者中经常观察到髓样抑制细胞(MDSC)。髓样细胞的这种异质群体可以有效抑制淋巴细胞的功能,从而对天然或治疗诱导的抗肿瘤免疫力构成很大的障碍。另一方面,MDSC的天然功能尚未得到很好的理解,其在感染,炎症和自身免疫性疾病中的作用仍令人困惑。了解MDSC生物学将为该人群的治疗提供必要的工具,但也允许对其进行开发在炎性疾病的治疗和预防移植排斥方面具有很强的耐受力。

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