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Anti-cytokine therapies in T1D: Concepts and strategies

机译:T1D中的抗细胞因子疗法:概念和策略

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摘要

Therapeutic targeting of proinflammatory cytokines is clinically beneficial in several autoimmune disorders. Several of these cytokines are directly implicated in the pathogenesis of type 1 diabetes, suggesting opportunities for design of clinical trials in type 1 diabetes that incorporate selective cytokine blockade as a component of preventative or interventional immunotherapy. The rationale and status of inhibitory therapy directed against IL-1, TNF, IL-12, IL-23, and IL-6 are discussed, towards a goal of using cytokine inhibition as a therapeutic platform to establish an in vivo milieu suitable for modulating the immune response in T1D.
机译:在几种自身免疫性疾病中,靶向治疗促炎性细胞因子在临床上是有益的。这些细胞因子中的几种与1型糖尿病的发病机制直接相关,这为设计1型糖尿病的临床试验提供了机会,该临床试验将选择性细胞因子阻滞作为预防性或介入性免疫疗法的组成部分。讨论了针对IL-1,TNF,IL-12,IL-23和IL-6的抑制疗法的基本原理和现状,以利用细胞因子抑制作为治疗平台来建立适于调节的体内环境为目标。 T1D的免疫反应。

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