Targeting the BLyS-APRIL signaling pathway in SLE

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Targeting the BLyS-APRIL signaling pathway in SLE

机译：靶向SLE中的BLyS-APRIL信号通路

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The B lymphocyte stimulator (BLyS)- A PRoliferation-Inducing Ligand (APRIL) signaling pathway has an important role in the selection, maturation and survival of B cells and plays a significant role in the pathogenesis of systemic lupus erythematosus (SLE). The inhibition of BLyS, a survival factor for transitional and mature B cells, has recently proven to be successful in large phase III clinical trials that led to the approval of an anti-BLyS monoclonal antibody (belimumab) for the treatment of SLE. Yet, there is currently a need to both understand better the mechanisms of action of belimumab in SLE and better define the subsets of patients that are more likely to respond to the drug.

机译：B淋巴细胞刺激物（BLyS）-诱导增殖的配体（APRIL）信号通路在B细胞的选择，成熟和存活中起重要作用，并且在系统性红斑狼疮（SLE）的发病机理中起重要作用。最近，在大型III期临床试验中证明了对BLyS（过渡性和成熟B细胞的生存因子）的抑制作用是成功的，该试验已批准了抗BLyS单克隆抗体（belimumab）用于治疗SLE。但是，目前既需要更好地了解贝利木单抗在SLE中的作用机制，又需要更好地确定更可能对该药产生反应的患者亚群。

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《Clinical immunology: The official journal of the Clinical Immunology Society》 |2013年第3期|共6页
作者
LaCavaA.;
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正文语种 eng
中图分类医学免疫学;
关键词
APRIL; BLyS/BAFF; Systemic lupus erythematosus (SLE);

机译：4月;BLyS / BAFF;系统性红斑狼疮（SLE）;

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1. Targeting the BLyS-APRIL signaling pathway in SLE [J] . LaCavaA. Clinical immunology: The official journal of the Clinical Immunology Society . 2013,第3期

机译：靶向SLE中的BLyS-APRIL信号通路
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6. Therapeutic Potential for Targeting the Suppressor of Cytokine Signaling-1 pathway for the treatment of SLE [O] . Bhagyalaxmi Sukka-Ganesh, Joseph Larkin III -1

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Targeting the BLyS-APRIL signaling pathway in SLE

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