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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Regulatory and effector T-cells are differentially modulated by Dexamethasone
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Regulatory and effector T-cells are differentially modulated by Dexamethasone

机译：地塞米松对调节性和效应性T细胞有不同的调节作用

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Abstract It is assumed that the ratio between effector T cells (Teff) and regulatory T cells (Tregs) controls the immune reactivity within the T-cell compartment. The purpose of this study was to investigate if Dexamethasone (Dex) affects Teff and Tregs subsets. Dex induced on Tregs a dose and time-dependent apoptosis which resulted in a relative increase of Teff. After TCR activation, Dex induced a strong proliferative inhibition of Teff, but a weaker proliferative inhibition on Tregs. These effects were modulated by IL-2, which not only restored the proliferative response, but also prevented Dex-induced apoptosis. The highest dose of IL-2 prevented apoptosis on all FOXP3 + CD4+ T cells. Meanwhile, the lowest dose only rescued activated Tregs (aTregs), probably related to their CD25 higher expression. Because Dex did not affect the suppressor capacity of aTregs either, our results support the notion that under Dex treatment, the regulatory T-cell compartment maintains its homeostasis.
机译：摘要假定效应T细胞（Teff）与调节性T细胞（Tregs）之间的比率控制着T细胞区隔中的免疫反应性。这项研究的目的是调查地塞米松（Dex）是否会影响Teff和Tregs子集。右旋糖酐在Tregs上诱导剂量和时间依赖性凋亡，这导致Teff相对增加。 TCR激活后，Dex诱导了对Teff的强增殖抑制，但对Treg的增殖抑制较弱。 IL-2调节了这些作用，不仅恢复了增殖反应，还阻止了Dex诱导的细胞凋亡。最高剂量的IL-2可阻止所有FOXP3 + CD4 + T细胞凋亡。同时，最低剂量仅能挽救活化的Treg（aTreg），可能与其CD25的高表达有关。因为Dex也不影响aTregs的抑制能力，所以我们的结果支持以下观点：在Dex处理下，调节性T细胞区室保持其稳态。

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