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首页> 外文期刊>Journal of psychiatric research >Investigating the inflammatory phenotype of major depression: focus on cytokines and polyunsaturated fatty acids.
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Investigating the inflammatory phenotype of major depression: focus on cytokines and polyunsaturated fatty acids.

机译：研究重度抑郁症的炎症表型：关注细胞因子和多不饱和脂肪酸。

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There is evidence that increased inflammatory activity contributes to treatment non-response in depression and studies suggest that omega-3 fatty acid supplementation is effective in antidepressant non-responders. We tested the hypotheses that in major depression (1) the plasma omega-6:omega-3 fatty acid ratio is greater in antidepressant non-responders than responders and (2) higher omega-6:omega-3 ratios are associated with a pro-inflammatory cytokine profile. Twenty DSM-IV major depressives who had failed a six week course of an SSRI, 14 subjects who responded to a six week course of an SSRI and were currently euthymic and 24 healthy comparison subjects took part in the study. Six millilitres of whole blood was collected in ethylenediaminetetraacetic acid (EDTA) tubes for determination of fatty acids together with IL-6 and TNF-alpha. Arachidonic acid (AA) levels were elevated in both the responders and the non-responders. IL-6 was elevated in a similar manner but differences in TNF-alpha did not reach statistical significance. The eicosapentaenoic acid (EPA):AA ratio in the three groups was as follows: controls 0.08+/-0.01; responders 0.08+/-0.01; non-responders 0.04+/-0.01. These differences are significant (p<0.001). AA and IL-6 were highly correlated in both responders and non-responders but not in healthy volunteers. The findings of this study provide further support for the view that major depression is associated with a pro-inflammatory phenotype which at least partially persists when patients become normothymic.
机译：有证据表明，炎症活动增加有助于抑郁症的无反应治疗，研究表明，补充omega-3脂肪酸对抗抑郁无反应者有效。我们检验了以下假设：在严重抑郁症中（1）抗抑郁药无反应者的血浆omega-6：omega-3脂肪酸比率大于反应者，以及（2）较高的omega-6：omega-3比率与抗抑郁药相关。 -炎症细胞因子谱。二十个DSM-IV重度抑郁症患者在SSRI的六个星期疗程中未通过，有14个受试者对SSRI的六个星期疗程作出了反应，目前正处于正常状态，而24名健康的比较受试者参加了该研究。在乙二胺四乙酸（EDTA）管中收集六毫升全血，用于测定脂肪酸以及IL-6和TNF-α。花生四烯酸（AA）的水平在反应者和非反应者中均升高。 IL-6以类似的方式升高，但TNF-α的差异未达到统计学意义。三组中二十碳五烯酸（EPA）：AA的比例如下：对照0.08 +/- 0.01;回应者0.08 +/- 0.01;无回应者0.04 +/- 0.01。这些差异是显着的（p <0.001）。 AA和IL-6在有反应者和无反应者中都高度相关，但在健康志愿者中却没有。这项研究的结果为以下观点提供了进一步的支持：重度抑郁与促炎表型有关，这种表型在患者成为常胸腺科患者时至少部分持续。

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