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首页> 外文期刊>Journal of psychiatric research >Evidence for stimulus-general impairments on auditory stream segregation tasks in schizophrenia
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Evidence for stimulus-general impairments on auditory stream segregation tasks in schizophrenia

机译：精神分裂症的听觉流分离任务刺激-一般损伤的证据

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Background: Auditory impairments in schizophrenia have been demonstrated previously, especially for tasks requiring precise encoding of frequency, although it is unclear the extent to which they have difficulty using pitch information and other cues to segregate sounds. We determined the extent to which those with schizophrenia have difficulty using pitch information and other auditory cues to segregate sounds that are presented sequentially. Methods: Ten participants with schizophrenia and nine healthyormal control participants completed a battery of tasks that tested for the ability to perform sequential auditory stream segregation using pitch, amplitude modulation, or inter-aural phase difference as cues to segregation. Results: All three sequential segregation tasks showed reduced tendency for those with schizophrenia to perceive segregated sounds, compared to control participants. Conclusions: These findings extend prior research by demonstrating a general impairment on sequential sound segregation tasks in schizophrenia, and not just on tasks that require precise encoding of frequency. Together, the pattern of results provide evidence that auditory impairments in schizophrenia result from selective abnormalities in neural circuits that carry out specific computations necessary for stream segregation, as opposed to an impairment in processing specific cues.
机译：背景：先前已证明精神分裂症的听觉障碍，特别是对于需要精确编码频率的任务，尽管目前尚不清楚他们使用音调信息和其他线索来分离声音的困难程度。我们确定了精神分裂症患者在使用音调信息和其他听觉提示来分离顺序出现的声音时遇到困难的程度。方法：十名精神分裂症参与者和九名健康/正常对照参与者完成了一系列任务，测试了使用音调，幅度调制或耳间相位差作为分离提示的能力，进行顺序听觉流分离的能力。结果：与对照组相比，所有三个顺序的隔离任务均显示精神分裂症患者感知隔离声音的趋势降低。结论：这些发现通过证明精神分裂症的顺序性声音分离任务普遍受损，而不仅仅是需要精确编码频率的任务，从而扩展了先前的研究。在一起，结果的模式提供了证据，即精神分裂症的听觉损伤是由神经回路的选择性异常导致的，神经回路执行了流分离所必需的特定计算，而不是处理特定线索的损伤。

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