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首页> 外文期刊>Journal of psychiatric research >Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-spectrum Disorders
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Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-spectrum Disorders

机译：多巴胺系统基因，儿童期虐待和患有贪食症的妇女的临床表现

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Objective: We explored interaction effects involving polymorphisms of targeted dopamine system genes and selected forms of childhood abuse (sexual, physical and emotional) acting upon severity of binge-eating and psychopathological symptoms in women with Bulimia-Spectrum Disorders (BSDs). Methods: Women diagnosed with a BSD (n = 216) were assessed for childhood traumata, eating-disorder (ED) symptoms, and selected psychopathological features (sensation seeking, impulsivity, compulsivity and affective instability), and then provided blood samples for genotyping of main polymorphisms of dopamine-2 receptor (DRD2), dopamine transporter (DAT1) and catechol o-methyltransferase (COMT) genes. Results: Sensation Seeking was elevated in carriers of the low-function allele of the DRD2 Taq1A polymorphism who also reported childhood sexual abuse, relative to that in individuals showing other combinations of alleles and abuse exposures. In addition, carriers of a low-function allele of COMT scored higher on compulsivity, lower on impulsivity, and marginally lower on frequency of binge-eating than did individuals in whom the allele was absent. Discussion: Our results suggest that genes acting within the dopamine system may contribute, either directly or indirectly (i.e., in interaction with traumatic childhood experiences), to variations in the presentation of comorbid traits and, possibly, of bulimic symptoms.
机译：目的：我们探讨了相互作用的效应，该效应涉及多巴胺靶向系统基因的多态性和儿童暴虐（性别，身体和情感）的某些选择形式对暴食症患者的暴饮暴食和心理病理症状的严重程度。方法：对诊断为BSD（n = 216）的妇女进行儿童创伤，进食障碍（ED）症状和选定的心理病理特征（感觉寻求，冲动，强迫和情感不稳定）的评估，然后提供血样用于BSD的基因分型。多巴胺2受体（DRD2），多巴胺转运蛋白（DAT1）和邻苯二酚邻甲基转移酶（COMT）基因的主要多态性。结果：DRD2 Taq1A多态性低功能等位基因携带者的知觉寻求也有所增加，相对于显示其他等位基因和虐待暴露组合的个体，该现象也报告了儿童期性虐待。另外，与缺少等位基因的个体相比，COMT低功能等位基因的携带者在强迫性上得分更高，在冲动上得分更低，并且暴饮暴食的频率略低。讨论：我们的结果表明，在多巴胺系统中起作用的基因可能直接或间接地（即与童年创伤经历相互作用）促成共病性状表现的变化，并且可能引起暴食症状。

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