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首页> 外文期刊>Journal of psychiatric research >Glutamate receptor delta 1 (GRID1) genetic variation and brain structure in schizophrenia
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Glutamate receptor delta 1 (GRID1) genetic variation and brain structure in schizophrenia

机译：精神分裂症的谷氨酸受体δ1（GRID1）遗传变异和脑结构

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Common genetic variation in the promoter region of the glutamate receptor delta 1 (GRID1) gene has recently been shown to confer increased risk for schizophrenia in several independent large samples. We analysed high-resolution magnetic resonance imaging (MRI) data from 62 patients with schizophrenia and 54 healthy controls using voxel-based morphometry (VBM) to assess the effect of single nucleotide polymorphism rs3814614 (located in the GRID1 promoter region), of which the T allele was identified as a risk factor in a previous association study. There were no effects of genotype or group × genotype interactions on total brain grey matter or white matter, but on regional grey matter. In healthy subjects, we identified a significant effect of rs3814614 genotype in the anterior thalamus (bilaterally), superior prefrontal cortex, and orbitofrontal cortex - in all cases with the homozygous risk genotype TT resulting in higher grey matter density. We did not find this association within the schizophrenia sample, where rs3814614 variation was only associated with grey matter reduction in TT homozygous subjects in medial parietal cortex and increased grey matter in right medial cerebellum. For white matter, we did not find significant genotype effects in healthy controls, and only minor effects within schizophrenia patients in the posterior temporal lobe white matter. Our data indicate that GRID1 rs3814614 genotype is related to grey matter variation in prefrontal and anterior thalamic brain areas in healthy subjects, but not in patients indicating a potential role of this schizophrenia candidate gene in thalamo-cortical functioning.
机译：最近已证明，在几个独立的大样本中，谷氨酸受体δ1（GRID1）基因启动子区域的常见遗传变异会增加精神分裂症的风险。我们使用基于体素的形态计量学（VBM）分析了62位精神分裂症患者和54位健康对照的高分辨率磁共振成像（MRI）数据，以评估单核苷酸多态性rs3814614（位于GRID1启动子区域）的影响，其中在先前的关联研究中，T等位基因被确定为危险因素。基因型或组×基因型相互作用对总脑灰质或白质没有影响，但对区域灰质没有影响。在健康受试者中，我们发现rs3814614基因型在前丘脑（两侧），上额额叶皮层和眶额叶皮层中具有显着效果-在所有情况下，纯合子风险基因型TT导致灰质密度更高。我们在精神分裂症样本中未发现这种关联，其中rs3814614变异仅与内侧顶叶皮层TT纯合受试者的灰质减少和右侧小脑的灰质增加有关。对于白质，我们在健康对照中未发现明显的基因型效应，而在后颞叶白质的精神分裂症患者中仅发现较小的效应。我们的数据表明，GRID1 rs3814614基因型与健康受试者的前额丘脑和前丘脑前脑区域的灰质变化有关，但与表明该精神分裂症候选基因在丘脑皮质功能中具有潜在作用的患者无关。

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