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首页> 外文期刊>Journal of psychiatric research >Regional differences in treatment response and three year course of schizophrenia across the world
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Regional differences in treatment response and three year course of schizophrenia across the world

机译：世界各地精神分裂症的治疗反应和三年病程的区域差异

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Data from the Worldwide-Schizophrenia Outpatient Health Outcomes (W-SOHO) study was used to determine the frequency of response and describe the course of disease in outpatients with schizophrenia in different regions of the world. The W-SOHO study was a 3-year, prospective, observational study that included over 17,000 outpatients with schizophrenia from 37 countries classified into six regions (Northern Europe, Southern Europe, Latin America, East Asia, Central & Eastern Europe, North Africa & Middle East). Cox proportional-hazards regression was employed to assess the factors associated with response. Multinomial logistic regression was used to assess the correlates of disease course. We found that approximately two-thirds of the patients (66.4%) achieved response during the 3-year follow up. Response rates varied across regions, and were highest in North Africa & Middle East (84.6%) and Latin America (78.6%) and lowest in Southern Europe (62.1%) and East Asia (60.9%). There were significant differences between the regions in the proportion of patients experiencing continuous remission, remission plus relapse and a persistent symptomatic course, and between the regions in the duration of remission. Overall, Latin America, East Asia, and North Africa & Middle East had more favorable outcomes because they had the largest proportion of people who achieved continuous remission, the longest time in remission and lowest percentage with a persistent symptomatic course. Having good social functioning at baseline was consistently associated with better clinical outcome. These results seem to indicate that patients from Latin America, East Asia, North Africa & Middle East may have a more favorable disease course than patients from European nations.
机译：来自全球精神分裂症门诊健康结果（W-SOHO）研究的数据用于确定反应的频率并描述世界不同地区精神分裂症门诊患者的病程。 W-SOHO研究是一项为期3年的前瞻性观察性研究，纳入了来自37个国家的17,000多名精神分裂症门诊患者，这些患者分为六个区域（北欧，南欧，拉丁美洲，东亚，中欧和东欧，北非和中东）。使用Cox比例风险回归来评估与反应相关的因素。多项式逻辑回归用于评估疾病进程的相关性。我们发现大约三分之二的患者（66.4％）在三年的随访期间达到了缓解。响应率因地区而异，在北非和中东（84.6％）和拉丁美洲（78.6％）最高，在南欧（62.1％）和东亚（60.9％）最低。区域之间在经历持续缓解，缓解加复发和持续症状过程的患者比例以及缓解期间在区域之间存在显着差异。总体而言，拉丁美洲，东亚以及北非和中东地区取得了更有利的结果，因为他们实现持续缓解的人数最多，缓解时间最长，而症状持续的比例最低。在基线时具有良好的社会功能一直与更好的临床结果相关。这些结果似乎表明，与来自欧洲国家的患者相比，来自拉丁美洲，东亚，北非和中东的患者的病程可能更有利。

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