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首页> 外文期刊>Journal of psychiatric research >Fatty acid composition in the postmortem amygdala of patients with schizophrenia, bipolar disorder, and major depressive disorder
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Fatty acid composition in the postmortem amygdala of patients with schizophrenia, bipolar disorder, and major depressive disorder

机译：精神分裂症，躁郁症和重度抑郁症患者验尸杏仁中的脂肪酸组成

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Previous studies with postmortem brain tissues showed abnormalities in n-3 polyunsaturated fatty acids (PUFAs) in the orbitofrontal cortex of individuals with schizophrenia and mood disorders. However, in the hippocampus, we were not able to find any significant differences in PUFAs except for small differences in n-6 PUFAs. In the present study we investigated levels of PUFAs in the amygdala of postmortem brains from patients with schizophrenia, bipolar disorder, and major depressive disorder (MDD) compared with those of unaffected controls. Amygdala samples from patients with schizophrenia (n = 15), bipolar disorder (n = 15), or MDD (n = 15), and controls matched for age, sex, and five other confounding factors (n = 15) were analyzed for fatty acid composition by gas chromatography. In contrast to previous studies of the orbitofrontal cortex and hippocampus, we were unable to find any significant differences in major PUFAs. The relative compositions of docosahexaenoic acid (DHA), the major n-3 PUFA, were 10.0 ± 1.1%, 10.0 ± 1.3%, 9.3 ± 1.3%, and 9.7 ± 1.1%, respectively, in patients with schizophrenia, bipolar disorder, and MDD and unaffected controls (not significantly different). The corresponding relative compositions of arachidonic acid (AA), the major n-6 PUFA, were 9.0 ± 0.8%, 9.2 ± 0.5%, 9.4 ± 0.7%, and 9.4 ± 0.7%, respectively (not significantly different). Significant differences were found in some of the other fatty acids. In particular, we found a 6.5% increase in palmitic acid and 6.2% decrease in oleic acid in patients with MDD compared to controls. With regard to schizophrenia, there was an 8.0% decrease in docosatetraenoic acid compared to controls. In conclusion, the changes in DHA and/or AA seen in orbitofrontal cortex and hippocampus were not observed in amygdala. These changes may be specific to particular brain regions.
机译：先前对死后脑组织的研究表明，患有精神分裂症和情绪障碍的人的眶额皮质中n-3多不饱和脂肪酸（PUFA）异常。但是，在海马中，除了n-6 PUFA的微小差异外，我们没有发现PUFA的任何显着差异。在本研究中，我们比较了未患精神分裂症，双相情感障碍和重度抑郁症（MDD）的患者与未患病对照的死后大脑杏仁核中PUFA的水平。分析来自精神分裂症（n = 15），双相情感障碍（n = 15）或MDD（n = 15）以及年龄，性别和其他五个混杂因素（n = 15）的对照的杏仁核样本中的脂肪气相色谱分析酸组成。与以前的眶额叶皮质和海马的研究相比，我们未能发现主要PUFA中有任何显着差异。精神分裂症，双相情感障碍和精神分裂症患者的主要n-3 PUFA二十二碳六烯酸（DHA）的相对组成分别为10.0±1.1％，10.0±1.3％，9.3±1.3％和9.7±1.1％。 MDD和未受影响的控件（无显着差异）。主要n-6 PUFA花生四烯酸（AA）的相应相对组成分别为9.0±0.8％，9.2±0.5％，9.4±0.7％和9.4±0.7％（无显着差异）。在其他一些脂肪酸中发现了显着差异。特别是，我们发现与对照组相比，MDD患者的棕榈酸增加6.5％，油酸减少6.2％。关于精神分裂症，与对照组相比，二十二碳四烯酸减少了8.0％。总之，在杏仁核中未观察到眶额叶皮层和海马中DHA和/或AA的变化。这些变化可能特定于特定的大脑区域。

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