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首页> 外文期刊>Journal of psychiatric research >Increased advanced glycation end-products (AGEs) assessed by skin autofluorescence in schizophrenia
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Increased advanced glycation end-products (AGEs) assessed by skin autofluorescence in schizophrenia

机译：通过精神分裂症中的皮肤自体荧光评估，晚期糖基化终产物（AGEs）增加

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Background: Oxidative stress has been intensively studied as a key biochemical system in the pathophysiology of schizophrenia. However, little is known about the implication of oxidative stress in the development of physical illnesses in schizophrenia patients, who are characterized by high cardiovascular risk and decreased life expectancy. Advanced glycation end-products (AGEs) are considered to be markers of oxidative stress and are linked to the development of atherosclerosis. Methods: We investigated AGE levels determined by a noninvasive skin autofluorescence (skin AF) method (AGE-Reader?) in schizophrenia patients. Skin AF was assessed in 55 schizophrenia patients without diabetes or renal disease and 55 healthy controls matched for age, gender and smoking status. Nineteen of the 55 schizophrenia patients had a severe form of the disease (Kraepelinian schizophrenia). Results: Skin AF was significantly higher in schizophrenia patients compared to controls (2.46±0.52 and 1.90±0.21, respectively, p<0.0001). Kraepelinian schizophrenia patients had significantly higher skin AF than non-Kraepelinian schizophrenia patients (p=0.05). Conclusions: This is the first study to demonstrate high AGE levels assessed by a noninvasive method in schizophrenia patients.
机译：背景：氧化应激已作为精神分裂症的病理生理学中的关键生化系统进行了深入研究。然而，关于氧化应激在精神分裂症患者身体疾病的发展中所起的作用知之甚少，精神分裂症患者的特征是心血管风险高和预期寿命缩短。晚期糖基化终产物（AGEs）被认为是氧化应激的标志物，与动脉粥样硬化的发展有关。方法：我们调查了通过无创皮肤自发荧光（皮肤AF）法（AGE-Reader？）确定的精神分裂症患者的AGE水平。在55名没有糖尿病或肾脏疾病的精神分裂症患者和55名健康对照者中评估了皮肤AF，这些患者的年龄，性别和吸烟状况相匹配。 55位精神分裂症患者中有19位患有严重的疾病（克雷伯林精神分裂症）。结果：精神分裂症患者的皮肤房颤明显高于对照组（分别为2.46±0.52和1.90±0.21，p <0.0001）。 Kraepelinian精神分裂症患者的皮肤房颤明显高于非Kraepelinian精神分裂症患者（p = 0.05）。结论：这是第一项通过无创方法评估精神分裂症患者高AGE水平的研究。

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