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首页> 外文期刊>Journal of psychiatric research >Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making
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Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making

机译：精神分裂症的激励动机缺陷反映了成本效益决策过程中的工作量计算障碍

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Background: Motivational impairments are a core feature of schizophrenia and although there are numerous reports studying this feature using clinical rating scales, objective behavioural assessments are lacking. Here, we use a translational paradigm to measure incentive motivation in individuals with schizophrenia. Methods: Sixteen stable outpatients with schizophrenia and sixteen matched healthy controls completed a modified version of the Effort Expenditure for Rewards Task that accounts for differences in motoric ability. Briefly, subjects were presented with a series of trials where they may choose to expend a greater amount of effort for a larger monetary reward versus less effort for a smaller reward. Additionally, the probability of receiving money for a given trial was varied at 12%, 50% and 88%. Clinical and other reward-related variables were also evaluated. Results: Patients opted to expend greater effort significantly less than controls for trials of high, but uncertain (i.e. 50% and 88% probability) incentive value, which was related to amotivation and neurocognitive deficits. Other abnormalities were also noted but were related to different clinical variables such as impulsivity (low reward and 12% probability). These motivational deficits were not due to group differences in reward learning, reward valuation or hedonic capacity. Conclusions: Our findings offer novel support for incentive motivation deficits in schizophrenia. Clinical amotivation is associated with impairments in the computation of effort during cost-benefit decision-making. This objective translational paradigm may guide future investigations of the neural circuitry underlying these motivational impairments.
机译：背景：动机障碍是精神分裂症的核心特征，尽管有许多报道使用临床评定量表研究该特征，但缺乏客观的行为评估。在这里，我们使用翻译范式来衡量精神分裂症患者的动机。方法：16位稳定的精神分裂症门诊患者和16位相匹配的健康对照者完成了奖励努力工作支出的修订版，该版本考虑了运动能力的差异。简而言之，对受试者进行了一系列试验，他们可以选择花费更多的精力以获得更大的金钱回报，而选择更少的精力获取更少的金钱回报。此外，在给定的试验中收到款项的可能性在12％，50％和88％之间变化。临床和其他奖励相关变量也进行了评估。结果：对于动机高但不确定（即50％和88％的可能性）的试验，患者选择花费的精力明显少于对照组，这与动机和神经认知功能障碍有关。还注意到其他异常，但它们与不同的临床变量有关，例如冲动性（低报酬和12％概率）。这些动机缺陷不是由于奖励学习，奖励评估或享乐能力上的群体差异而引起的。结论：我们的发现为精神分裂症的激励动机缺陷提供了新颖的支持。临床动机与成本效益决策过程中的工作量计算受损有关。这种客观的翻译范式可以指导这些动机障碍背后的神经回路的未来研究。

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