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首页> 外文期刊>Journal of psychiatric research >Cholesterol and phospholipids in frontal cortex and synaptosomes of suicide completers: Relationship with endosomal lipid trafficking genes
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Cholesterol and phospholipids in frontal cortex and synaptosomes of suicide completers: Relationship with endosomal lipid trafficking genes

机译：额叶皮质和自杀完成者突触小体中的胆固醇和磷脂：与内体脂质运输基因的关系

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Cholesterol (CHL) and phospholipid (PL) levels in synaptosomal membranes in particular can have an impact on cell signalling. Alterations in peripheral CHL measures have been consistently reported in suicidal behaviour. As CHL and PL turnover in the brain are important in synapse maintenance and function, the objective of this study was to determine if differences exist in synaptosomal cholesterol and phospholipid levels between suicide completers and controls. Expression measures of genes involved in lipid trafficking suggest an association between Lysosomal acid lipase A, cholesteryl ester hydrolase (LIPA) and brain PL levels, with LIPA being significantly increased in violent suicides and associated with alterations in brain PL. The results of this study suggest an altered PL content mediated by LIPA expression in violent suicides in the prefrontal cortex, which would have important consequences for inhibitory neurotransmission.
机译：突触体膜中的胆固醇（CHL）和磷脂（PL）水平尤其会影响细胞信号转导。在自杀行为方面，一直以来都报告了周围CHL量度的改变。由于大脑中的CHL和PL转换对突触的维持和功能很重要，因此本研究的目的是确定自杀完成者和对照组之间突触体胆固醇和磷脂水平是否存在差异。涉及脂质运输的基因的表达测量表明，溶酶体酸性脂肪酶A，胆固醇酯水解酶（LIPA）和脑PL水平之间存在关联，其中暴力自杀中LIPA显着增加，并与脑PL改变有关。这项研究的结果表明，前额叶皮层暴力自杀中LIPA表达介导的PL含量改变，这对抑制神经传递具有重要意义。

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