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首页> 外文期刊>Journal of psychiatry & neuroscience: JPN >Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter
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Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter

机译：磁共振成像与年轻成年男性患者首发精神病的相关性：灰色和白色物质的组合分析

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Background: Several patterns of grey and white matter changes have been separately described in young adults with first-episode psychosis. Concomitant investigation of grey and white matter densities in patients with first-episode psychosis without other psychiatric comorbidities that include all relevant imaging markers could provide clues to the neurodevelopmental hypothesis in schizophrenia. Methods: We recruited patients with first-episode psychosis diagnosed according to the DSM-IV-TR and matched controls. All participants underwent magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) analysis and mean diffusivity voxel-based analysis (VBA) were used for grey matter data. Fractional anisotropy and axial, radial and mean diffusivity were analyzed using tract-based spatial statistics (TBSS) for white matter data. Results: We included 15 patients and 16 controls. The mean diffusivity VBA showed significantly greater mean diffusivity in the first-episode psychosis than in the control group in the lingual gyrus bilaterally, the occipital fusiform gyrus bilaterally, the right lateral occipital gyrus and the right inferior temporal gyrus. Moreover, the TBSS analysis revealed a lower fractional anisotropy in the first-episode psychosis than in the control group in the genu of the corpus callosum, minor forceps, cor-ticospinal tract, right superior longitudinal fasciculus, left middle cerebellar peduncle, left inferior longitudinal fasciculus and the posterior part of the fronto-occipital fasciculus. This analysis also revealed greater radial diffusivity in the first-episode psychosis than in the control group in the right corticospinal tract, right superior longitudinal fasciculus and left middle cerebellar peduncle. Limitations: The modest sample size and the absence of women in our series could limit the impact of our results. Conclusion: Our results highlight the structural vulnerability of grey matter in posterior areas of the brain among young adult male patients with first-episode psychosis. Moreover, the concomitant greater radial diffusivity within several regions already revealed by the fractional anisotropy analysis supports the idea of a late myelination in patients with first-episode psychosis.
机译：背景：在患有首发性精神病的年轻人中已经分别描述了几种灰色和白色物质变化模式。在没有其他精神病合并症（包括所有相关影像学标记物）的首发性精神病患者中，同时进行灰白质密度调查可能为精神分裂症的神经发育假说提供线索。方法：我们招募了根据DSM-IV-TR和相匹配的对照被诊断出的首发精神病患者。所有参与者均接受了磁共振成像（MRI）。基于体素的形态学（VBM）分析和基于平均扩散率的基于体素的分析（VBA）用于灰质数据。使用基于区域空间统计（TBSS）的白质数据分析了分数各向异性以及轴向，径向和平均扩散率。结果：我们包括15名患者和16名对照。平均扩散率VBA在首发性精神病中的平均扩散率明显高于对照组（双侧舌状回，双侧枕形梭状回，右枕侧回状和右下颞回）。此外，TBSS分析显示，在第一集性精神病中，call体，小钳子，皮质脊髓束，右上纵筋膜，左小脑中轴，左下纵肌等比对照组的分数各向异性要低。筋膜和额枕筋膜的后部。该分析还显示，在第一病态的精神病患者中，右皮质脊髓束，右上纵筋膜和左中小脑梗比对照组的放射扩散性更大。局限性：我们系列中的样本量适中且缺少女性，可能会限制我们结果的影响。结论：我们的结果突出了年轻的成年男性首发精神病患者大脑后部区域灰质的结构脆弱性。此外，分数各向异性分析已经揭示了在几个区域内随之而来的更大的径向扩散，这支持了首发精神病患者晚期髓鞘化的想法。

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