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首页> 外文期刊>Journal of psychiatry & neuroscience: JPN >Working memory processing of traumatic material in women with posttraumatic stress disorder
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Working memory processing of traumatic material in women with posttraumatic stress disorder

机译：创伤后应激障碍女性创伤材料的工作记忆处理

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Background: Posttraumatic stress disorder (PTSD) is associated with medial frontal and amygdala functional alterations during the processing of traumatic material and frontoparietal dysfunctions during working memory tasks. This functional magnetic resonance imaging (fMRI) study investigated the effects of trauma-related words processing on working memory in patients with PTSD. Methods: We obtained fMRI scans during a 3-back task and an identity task on both neutral and trauma-related words in women with PTSD who had been sexually abused and in healthy, nonexposed pair-matched controls. Results: Seventeen women with PTSD and 17 controls par - tici pated in the study. We found no behavioural working memory deficit for the PTSD group. In both tasks, deactivation of posterior parietal midline regions was more pronounced in patients than controls. Additionally, patients with PTSD recruited the left dorsolateral frontal sites to a greater extent during the processing of trauma-related material than neutral material. Limitations: This study included only women and did not include a trauma-exposed non-PTSD control group; the results may, therefore, have been influenced by sex or by effects specific to trauma exposure. Conclusion: Our results broadly confirm frontal and parietal functional variations in women with PTSD and suggest a compensatory nature of these variations with regard to the retreival of traumatic memories and global attentional deficits, respectively, during cognitively challenging tasks.
机译：背景：创伤后应激障碍（PTSD）与外伤性材料处理过程中的内侧额叶和杏仁核功能改变以及工作记忆任务期间的额前额叶功能障碍有关。这项功能磁共振成像（fMRI）研究调查了创伤相关单词处理对PTSD患者工作记忆的影响。方法：我们在性虐待和健康，未暴露的成对配对对照的PTSD妇女的3后背任务和身份任务中，对中性和创伤相关单词进行了功能磁共振成像扫描。结果：参加这项研究的17名PTSD妇女和17名对照者。我们发现PTSD组没有行为工作记忆障碍。在这两个任务中，患者后壁中线的失活在患者中比对照组更为明显。另外，创伤后应激障碍患者在创伤相关材料的处理过程中比中性材料在更大程度上募集了左背外侧额叶部位。局限性：本研究仅包括女性，不包括创伤暴露的非PTSD对照组;因此，结果可能受到性别或创伤暴露特有影响的影响。结论：我们的结果广泛证实了创伤后应激障碍女性的额叶和顶叶功能变异，并暗示了这些变异在认知挑战性任务中分别对创伤性记忆恢复和整体注意力缺陷的补偿性。

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