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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Celiac disease-associated transglutaminase autoantibody target domains at diagnosis are age and sex dependent.
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Celiac disease-associated transglutaminase autoantibody target domains at diagnosis are age and sex dependent.

机译：诊断时与腹腔疾病相关的转谷氨酰胺酶自身抗体靶域是年龄和性别依赖性的。

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摘要

The contribution of age and/or sex to the transglutaminase (tTG) autoantibody response in celiac disease (CD) is not known. To gain insights into transglutaminase humoral autoimmunity at CD diagnosis, our aim was to characterize the autoimmune response against three tTG constructs [(full-length tTG(a.a.1-687), tTG(a.a.227-687), and tTG(a.a.473-687)] and to investigate into its relationship with CD patients' age and sex. One hundred seventy-five newly diagnosed CD patients (115 females and 60 males), subdivided into different groups according to age and sex, were studied using a serum (35)S-radioimmunoassay. We found that among full-length tTG autoantibody-positive CD subjects (175/175), 50.9% (89/175) and 83.4% (146/175) had autoantibodies against tTG(227-687) and tTG(473-687) domains, respectively. Female patients of less than 4 years expressed tTG(227-687)Abs in significantly higher percentage and mean autoantibody titers vs. all other groups investigated, and tTG(473-687)Abs in significantly higher titers with respect to adult female patients. Our data identify a subset of CD patients showing a strong humoral tTG immunoreactivity at diagnosis, thus suggesting that age and sex influence the anti-tTG autoantibody response.
机译：年龄和/或性别对乳糜泻（CD）中转谷氨酰胺酶（tTG）自身抗体应答的贡献尚不清楚。为了深入了解CD诊断时的转谷氨酰胺酶体液自身免疫，我们的目标是表征针对三种tTG构建体[（全长tTG（aa1-687），tTG（aa227-687）和tTG（aa473- 687）]，并探讨其与CD患者的年龄和性别的关系。使用血清研究了175位新诊断的CD患者（115名女性和60名男性），根据年龄和性别将其分为不同的组。 35）S放射免疫分析法我们发现，在全长tTG自身抗体阳性的CD受试者（175/175）中，有50.9％（89/175）和83.4％（146/175）具有针对tTG的自身抗体（227-687）和分别小于tTG（473-687）域，与所有其他调查组相比，年龄小于4岁的女性患者表达tTG（227-687）Ab的百分比和平均自身抗体滴度显着更高，而表达tTG（473-687）Abs的百分比显着较高与成年女性患者相比，滴度更高诊断时具有道德的tTG免疫反应性，因此提示年龄和性别会影响抗tTG自身抗体的反应。

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