A new CD21(low) B cell population in the peripheral blood of patients with SLE.

Wehr C; Eibel H; Masilamani M; Illges H; Schlesier M; Peter HH; Warnatz K

首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >A new CD21(low) B cell population in the peripheral blood of patients with SLE.

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A new CD21(low) B cell population in the peripheral blood of patients with SLE.

机译：SLE患者外周血中新的CD21（低）B细胞群。

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A hallmark of systemic lupus erythematosus (SLE) is the production of autoantibodies. Recent reports suggest an abnormal peripheral blood B cell homeostasis in SLE patients without being conclusive. We analyzed by four color flow-cytometry peripheral blood B cell subpopulations of SLE patients, healthy donors, and patients with other systemic autoimmune diseases. IgM memory but not switched memory B cells of SLE patients were significantly decreased compared to healthy donors, whereas transitional B cells, characterized by CD19(+)IgM(hi)IgD(+)CD24(hi)CD38(hi), were significantly expanded in SLE patients but also found in other autoimmune disorders. The population of plasmablasts (CD19(lo)CD21(lo)CD27(++)CD38(++)) was increased in active disease. Most interestingly, B cells in autoimmune disorders contain a so far uncharacterized subpopulation with an activated phenotype (CD19(hi)CD21(lo)CD38(lo)CD86(int)). None of the identified subpopulations was associated with current or previous therapy and therefore may represent different aspects of the disturbed B cell homeostasis in patients with SLE.

机译：系统性红斑狼疮（SLE）的标志是自身抗体的产生。最近的报道提示SLE患者外周血B细胞稳态异常，但尚无定论。我们通过四种颜色流式细胞仪分析了SLE患者，健康供体和其他系统性自身免疫性疾病患者的外周血B细胞亚群。与健康的供体相比，SLE患者的IgM记忆但未切换记忆B细胞显着减少，而以CD19（+）IgM（hi）IgD（+）CD24（hi）CD38（hi）为特征的过渡性B细胞显着增加在SLE患者中也发现在其他自身免疫性疾病中。在活动性疾病中，成浆细胞（CD19（lo）CD21（lo）CD27（++）CD38（++））的数量增加。最有趣的是，自身免疫性疾病中的B细胞包含一个迄今为止尚未鉴定的具有激活表型的亚群（CD19（hi）CD21（lo）CD38（lo）CD86（int））。没有一个已鉴定的亚群与当前或先前的治疗相关，因此可能代表了SLE患者B细胞稳态紊乱的不同方面。

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《Clinical immunology: The official journal of the Clinical Immunology Society》 |2004年第2期|共11页
作者
Wehr C; Eibel H; Masilamani M; Illges H; Schlesier M; Peter HH; Warnatz K;
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正文语种 eng
中图分类临床医学;
关键词
Lupus Erythematosus; Systemic; B-Lymphocytes; Peripheral blood; NOS; Receptors; Complement 3d; 红斑狼疮; 系统性; B淋巴细胞; 受体; 补体3D;

机译：Lupus Erythematosus;Systemic;B-Lymphocytes;Peripheral blood;NOS;Receptors;Complement 3d;红斑狼疮;系统性;B淋巴细胞;受体;补体3D;

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1. A new CD21(low) B cell population in the peripheral blood of patients with SLE. [J] . Wehr C, Eibel H, Masilamani M, Clinical immunology: The official journal of the Clinical Immunology Society . 2004,第2期

机译：SLE患者外周血中新的CD21（低）B细胞群。
2. Mobilization of peripheral blood progenitor cells (PBPC) in patients undergoing chemotherapy followed by autologous peripheral blood stem cell transplant (SCT) for high risk breast cancer (HRBC). [J] . Benet I, Prosper BF, Marugan I, Bone marrow transplantation . 1999,第11期

机译：在接受化疗的患者中动员外周血祖细胞（PBPC），然后进行自体外周血干细胞移植（SCT）以治疗高危乳腺癌（HRBC）。
3. Evaluation of CD4 + + CD25 +/? +/? CD39 + + T‐cell populations in peripheral blood of patients following kidney transplantation and during acute allograft rejection [J] . McRae Jennifer L, Chia Joanne SJ, Pommey Sandra A, Nephrology. . 2017,第7期

机译：评价CD4 + + CD25 + /？ + /？肾移植后患者外周血的CD39 + + T细胞群和急性同种异体移植排斥反应
4. Expression of CD4+CD25+ T regulatory cells and Foxp3 in peripheral blood of patients with Rheumatoid Arthritis Patient [C] . Kexin Sun, Yan Li, Suhong Guo, International Conference on Applied Science, Engineering and Technology . 2013

机译：类风湿性关节炎患者外周血CD4 + CD25 + T调节细胞和FOXP3的表达
5. IgE anti-HIV-1 in serum of HIV-1 infected children inhibits HIV-1 production in vitro and IgE mediates cytotoxicity against lymphoma cells expressing HIV-1 and peripheral blood mononuclear cells from an HIV-1 seropositive patient [D] . Bluth, Martin Heath. 1997

机译：HIV-1感染儿童血清中的IgE抗HIV-1抑制了HIV-1的体外产生，IgE介导了对HIV-1血清反应阳性患者表达HIV-1的淋巴瘤细胞和外周血单核细胞的细胞毒性
6. Peripheral CD27−CD21− B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis [O] . Hiroyoshi Doi, Shiroh Tanoue, David E. Kaplan -1

机译：外周血CD27-CD21-B细胞代表丙型肝炎肝硬化患者的淋巴细胞耗尽
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A new CD21(low) B cell population in the peripheral blood of patients with SLE.

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