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The induction and maintenance of T cell anergy.

机译:T细胞无反应性的诱导和维持。

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摘要

While the "true" role of T cell anergy in promoting peripheral tolerance continues to be debated, it is clear that studying the various models of anergy have led to important insight in terms of understanding the pathways and molecules responsible for T cell activation and inhibition. This review will examine our current understanding of CD4+ T cell anergy. In particular, it will focus on the signaling pathways responsible for both the induction and maintenance of anergy. Furthermore, it will examine how specifically targeting these pathways can be exploited clinically in terms of promoting tolerance in transplantation and autoimmunity and inhibiting tumor-induced tolerance in the case of tumor-immunotherapy.
机译:尽管T细胞无反应性在促进外周耐受中的“真正”作用仍在争论中,但是很明显,研究各种无反应性模型已经在理解负责T细胞活化和抑制的途径和分子方面产生了重要的见解。这篇综述将检验我们目前对CD4 + T细胞无反应性的理解。特别地,它将集中在负责诱导和维持无能的信号通路上。此外,在肿瘤免疫疗法的情况下,它将研究如何在促进移植和自身免疫的耐受性以及抑制肿瘤诱导的耐受性方面在临床上特别针对这些途径进行开发。

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