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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Apoptosis in the skeletal muscle of untreated children with juvenile dermatomyositis: impact of duration of untreated disease.
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Apoptosis in the skeletal muscle of untreated children with juvenile dermatomyositis: impact of duration of untreated disease.

机译：未治疗的青少年皮肌炎的儿童骨骼肌细胞凋亡：未治疗疾病持续时间的影响。

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摘要

Juvenile dermatomyositis (JDM) is the most common myopathy in children with characteristic skin rash and muscle weakness, in which longer duration of untreated disease was associated with less muscle weakness. The duration of untreated inflammation may alter the apoptotic pathways involved in skeletal muscle damage. Diagnostic muscle biopsies from 14 untreated patients were stained for apoptosis markers. TUNEL-positive nuclei and caspase 3 were detected within the laminin layer, indicating apoptosis of skeletal muscle nuclei. Untreated JDM disease duration greater than 2 months ("long"), was associated with higher Fas-positive cell counts in the perivascular region compared with the "short" disease duration group, 2 months or less. Within the "long" duration group, higher Fas-positive cell counts were positively associated with increased TUNEL-positive nuclei and caspase 3. We conclude that the duration of untreated disease (chronic inflammation) influences the mode of continuing cell damage and death in children with JDM.
机译：少年皮肌炎（JDM）是特征性皮疹和肌肉无力的儿童中最常见的肌病，未治疗疾病的持续时间越长，肌肉无力越少。未经治疗的炎症持续时间可能会改变涉及骨骼肌损伤的凋亡途径。对来自14名未接受治疗的患者的诊断性肌肉活检进行了细胞凋亡标记染色。在层粘连蛋白层中检测到TUNEL阳性细胞核和caspase 3，表明骨骼肌细胞核凋亡。与“短”疾病持续时间组（2个月或更短）相比，未经治疗的JDM疾病持续时间大于2个月（“长”）与血管周区域Fas阳性细胞计数较高相关。在“长”病程组中，较高的Fas阳性细胞计数与TUNEL阳性核和caspase 3的增加呈正相关。我们得出结论，未治疗疾病的病程（慢性炎症）影响儿童持续性细胞损伤和死亡的方式与JDM。

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