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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Invariant NKT cells from HIV-1 or Mycobacterium tuberculosis-infected patients express an activated phenotype.
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Invariant NKT cells from HIV-1 or Mycobacterium tuberculosis-infected patients express an activated phenotype.

机译：来自HIV-1或结核分枝杆菌感染患者的不变NKT细胞表达活化的表型。

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摘要

The frequency, subsets and activation status of peripheral blood invariant NKT (iNKT) cells were evaluated in pulmonary tuberculosis (TB) patients and in chronically HIV-1-infected subjects. The absolute numbers of iNKT cells were significantly decreased in TB patients and in HIV-1+ individuals who were antiretroviral therapy naive or had detectable viremia despite receiving HAART. iNKT cell subset analysis demonstrated a decreased percentage of CD4(+) iNKT cells in HIV-1+ subjects, and a decreased percentage of double negative iNKT cells in TB patients. Peripheral blood iNKT cells from HIV-1+ and TB patients had significantly increased expression of CD69, CD38, HLA-DR, CD16, CD56, and CD62L. The expression of CD25 was significantly increased only on iNKT cells from TB patients. These findings indicate that peripheral blood iNKT cells in these two chronic infections show an up-regulated expression of activation markers, suggesting their role in the immune response to infection.
机译：在肺结核（TB）患者和慢性感染HIV-1的受试者中评估了外周血不变NKT（iNKT）细胞的频率，子集和激活状态。在接受抗逆转录病毒治疗但未接受抗逆转录病毒治疗或可检测到病毒血症的结核病患者和HIV-1 +患者中，iNKT细胞的绝对数量显着降低。 iNKT细胞子集分析显示，HIV-1 +受试者中CD4（+）iNKT细胞百分比降低，而TB患者中双阴性iNKT细胞百分比降低。来自HIV-1 +和TB患者的外周血iNKT细胞CD69，CD38，HLA-DR，CD16，CD56和CD62L的表达明显增加。 CD25的表达仅在来自TB患者的iNKT细胞上显着增加。这些发现表明，在这两种慢性感染中，外周血iNKT细胞显示出活化标志物的表达上调，表明它们在对感染的免疫反应中起作用。

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