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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Heightened T-cell proliferation without an elevation of CD4+ T cell spontaneous apoptosis in AIDS patients.
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Heightened T-cell proliferation without an elevation of CD4+ T cell spontaneous apoptosis in AIDS patients.

机译：艾滋病患者中T细胞增殖增加而CD4 + T细胞自发凋亡却没有增加。

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摘要

T lymphocyte turnover has been studied extensively in HIV infection. The dynamic characteristics of various subsets of T cells in antiretroviral-naive, HIV-1-infected individuals, however, have not been well defined. Here, we performed a cross-sectional study using peripheral blood T cells from 39 antiretroviral-naive, chronically HIV-infected patients, as well as 16 healthy, HIV-negative controls. T-cell subset turnover rates were measured by Ki-67 antigen staining; levels of spontaneous apoptosis and activation in T-cell subsets were also determined by flow cytometry. Surprisingly, with disease progression, the level of T-cell spontaneous apoptosis did not increase significantly, despite a heightened rate of T-cell subset turnover and increased expression of the CD38 activation marker. These data refute the idea that increased T cell turnover is merely a homeostatic process in response to CD4 T cell loss during HIV disease progression, and suggest that future mechanistic studies may be needed for a comprehensive understanding of T-cell dynamics during HIV infection. Such understanding may help to develop new strategies for the immune modulation of clinical disease.
机译：T淋巴细胞更新已被广泛研究HIV感染。天真，抗HIV-1感染的个体中T细胞的各种亚群的动态特征，但尚未得到很好的定义。在这里，我们进行了一项横断面研究，该研究使用了39名抗逆转录病毒初治的慢性HIV感染患者以及16名健康的HIV阴性对照的外周血T细胞。通过Ki-67抗原染色测量T细胞亚群的更新率;还通过流式细胞术确定了T细胞亚群中自发凋亡和激活的水平。出人意料的是，随着疾病的进展，尽管T细胞亚群更新率增加和CD38激活标记物表达增加，T细胞自发凋亡的水平也没有显着增加。这些数据驳斥了增加的T细胞更新仅仅是在HIV疾病发展过程中对CD4 T细胞丢失做出反应的体内平衡过程的想法，并建议可能需要进一步的机制研究来全面了解HIV感染期间T细胞的动力学。这种理解可能有助于开发新的策略来调节临床疾病的免疫。

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