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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >A unique T cell subset described as CD4loCD40+ T cells (TCD40) in human type 1 diabetes.
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A unique T cell subset described as CD4loCD40+ T cells (TCD40) in human type 1 diabetes.

机译：在人类1型糖尿病中，独特的T细胞亚群称为CD4loCD40 + T细胞（TCD40）。

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摘要

Human T1D pancreatic lymph nodes contain diabetes-autoantigen responsive T cells but identification of such T cells in the periphery has proven difficult. Here we describe a unique T cell subset defined by CD4(lo) and CD40 expression (T(CD40)) that is significantly expanded in peripheral blood of T1D but not control or T2D subjects. The HLA-DR3 and DR4 alleles are considered high risk factors for T1D and T(CD40) expansion occurs in T1D subjects carrying HLA DR3 or DR4 haplotypes but, T1D subjects who do not carry either DR3 or DR4 haplotypes still have an expanded percentage of T(CD40) cells. Non-autoimmune subjects, even DR3(+) and DR4(+), do not have elevated percentages of T(CD40) cells. The majority of T(CD40) cells in T1D carry a memory phenotype and a portion of those proliferates when exposed to diabetes-associated self-antigens. A greater number of memory T(CD40) cells express CXCR3 when compared to CD40(-) memory cells and that number is significantly expanded in T1D compared to control subjects. If only total CD4(+) T cells are compared no difference in CXCR3 is seen. Furthermore, T(CD40) cells produce a Th1, pro-inflammatory cytokine profile. In healthy controls, T(CD40) cells have equally Th1 and Th2 profiles.
机译：人类T1D胰腺淋巴结含有糖尿病自身抗原反应性T细胞，但在外周很难鉴定出此类T细胞。在这里，我们描述了由CD4（lo）和CD40表达（T（CD40））定义的独特T细胞亚群，该亚群在T1D的外周血中显着扩增，但未在对照组或T2D受试者中扩展。 HLA-DR3和DR4等位基因被认为是T1D和T（CD40）扩增的高风险因素，在携带HLA DR3或DR4单倍型的T1D受试者中发生，但是不携带DR3或DR4单倍型的T1D受试者仍具有扩展的T百分比（CD40）细胞。非自身免疫性受试者，甚至DR3（+）和DR4（+），都没有升高的T（CD40）细胞百分比。 T1D中的大多数T（CD40）细胞均具有记忆表型，其中一部分暴露于糖尿病相关的自身抗原时会增殖。与CD40（-）记忆细胞相比，更多数量的记忆T（CD40）细胞表达CXCR3，并且与对照组相比，T1D中该数目显着增加。如果仅比较全部CD4（+）T细胞，则看不到CXCR3的差异。此外，T（CD40）细胞产生Th1，促炎性细胞因子谱。在健康对照组中，T（CD40）细胞具有相同的Th1和Th2谱。

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