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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Up-regulation of TRAIL mRNA expression in peripheral blood mononuclear cells from patients with active systemic lupus erythematosus.
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Up-regulation of TRAIL mRNA expression in peripheral blood mononuclear cells from patients with active systemic lupus erythematosus.

机译：活动性系统性红斑狼疮患者外周血单个核细胞中TRAIL mRNA表达的上调。

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摘要

It is recently suggested that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is involved in the pathogenesis of systemic lupus erythematosus (SLE). In this study, we examined whether expression levels of TRAIL depend on SLE activity. To estimate TRAIL mRNA expression levels in peripheral blood mononuclear cells (PBMC), we performed quantitative real-time reverse transcription-polymerase chain reaction analyses of PBMC from 18 SLE patients and 20 healthy subjects. Serum soluble TRAIL (sTRAIL) concentrations were measured by an enzyme-linked immunosorbent assay. The mean TRAIL mRNA expression level and serum sTRAIL concentration in SLE patients were significantly higher than those in healthy controls. Expression levels of TRAIL mRNA correlated with the SLE disease activity index and circulating immune complexes levels, while serum sTRAIL concentrations did not. These results indicate that increased expression of TRAIL mRNA in PBMC closely correlates with SLE activity and suggest an important role for TRAIL in the pathogenesis of SLE.
机译：最近有人提出，肿瘤坏死因子相关的凋亡诱导配体（TRAIL）参与了系统性红斑狼疮（SLE）的发病机制。在这项研究中，我们检查了TRAIL的表达水平是否取决于SLE活性。为了评估外周血单核细胞（PBMC）中TRAIL mRNA的表达水平，我们对18名SLE患者和20名健康受试者的PBMC进行了实时定量逆转录-聚合酶链反应分析。通过酶联免疫吸附测定法测量血清可溶性TRAIL（sTRAIL）浓度。 SLE患者的平均TRAIL mRNA表达水平和血清sTRAIL浓度显着高于健康对照者。 TRAIL mRNA的表达水平与SLE疾病活动指数和循环免疫复合物水平相关，而血清sTRAIL浓度则不相关。这些结果表明，TRAIL mRNA在PBMC中的表达增加与SLE活性密切相关，并提示TRAIL在SLE的发病中起重要作用。

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