首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Serum and BAL macrophage migration inhibitory factor levels in HIV infected Tanzanians with pulmonary tuberculosis or other lung diseases.
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Serum and BAL macrophage migration inhibitory factor levels in HIV infected Tanzanians with pulmonary tuberculosis or other lung diseases.

机译:感染了肺结核或其他肺部疾病的坦桑尼亚艾滋病毒感染者的血清和BAL巨噬细胞迁移抑制因子水平。

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Macrophage migration inhibitory factor (MIF) activates macrophages, promotes delayed-type hypersensitivity reaction, and regulates Th1/Th2 balance in inflammatory response. Serum MIF concentration is high in patients with pulmonary tuberculosis (PTB). Higher MIF levels are associated with high mortality. No study has addressed MIF levels and its role in PTB/HIV-co infection. We determined serum and BAL MIF levels in Tanzanian HIV-infected patients with and without PTB, and correlated the levels with 1-month outcome. We compared with serum MIF levels of HIV seronegative patients with PTB and of healthy controls. All HIV-infected patients irrespective of PTB infection had significantly higher serum MIF levels than HIV-seronegative patients with PTB, and than healthy controls. In HIV seropositive patients low serum MIF levels were associated with high 1-month mortality. In conclusion, HIV infection was associated with elevated serum MIF levels regardless of PTB. Low serum MIF levels were associated with high mortality.
机译:巨噬细胞迁移抑制因子(MIF)激活巨噬细胞,促进迟发型超敏反应,并调节炎症反应中的Th1 / Th2平衡。肺结核(PTB)患者的血清MIF浓度较高。 MIF水平越高,死亡率越高。尚无针对MIF水平及其在PTB / HIV-co感染中的作用的研究。我们确定了坦桑尼亚艾滋病毒感染的有无PTB的患者的血清和BAL MIF水平,并将该水平与1个月预后相关。我们将HIV血清阴性的PTB患者和健康对照者的血清MIF水平进行了比较。不论是否感染了PTB,所有感染HIV的患者的血清MIF水平均显着高于HIV阴性的PTB患者和健康对照组。在HIV血清阳性患者中,血清MIF水平低与1个月高死亡率相关。总之,无论PTB如何,HIV感染都与血清MIF水平升高有关。血清MIF水平低与死亡率高有关。

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