• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Nijmegen breakage syndrome: Long-term monitoring of viral and immunological biomarkers in peripheral blood before development of malignancy.
【24h】

Nijmegen breakage syndrome: Long-term monitoring of viral and immunological biomarkers in peripheral blood before development of malignancy.

机译：奈梅亨破坏综合症：在恶性肿瘤发生之前长期监测外周血中的病毒和免疫生物标记。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Selected viruses and immune parameters were monitored in 57 patients with Nijmegen breakage syndrome as a proposed tool for early detection of changes preceding development of malignancy. The following parameters were analysed: (1) viral infections; (2) monoclonal proteins; and (3) B-cell and T-cell receptor gene rearrangements in peripheral blood lymphocytes. Viral infections were detected in 68.4% of patients with a predominance of EBV (63.2%), followed by HBV (19.2%) and HCV (8.8%). Monoclonal gammopathy detected in 38.6% of cases correlated with the presence of EBV DNA (p=0.002) and HCV RNA (p=0.04). Clonal Ig and/or TCR gene rearrangements occurred in 73.9% of patients. The presence of at least one of the studied parameters preceded the development of malignancy in 22 patients. Systematic PCR analysis for viral infections and Ig/TCR gene rearrangements, supplemented by detection of monoclonal proteins, is advantageous in monitoring NBS patients before severe complications of the disease, including cancer, appear.
机译：在57名奈梅亨断裂综合征患者中监测了选定的病毒和免疫参数，将其作为早期发现恶性肿瘤变化的建议工具。分析了以下参数：（1）病毒感染; （2）单克隆蛋白; （3）外周血淋巴细胞中的B细胞和T细胞受体基因重排。在以EBV为主的患者中，有68.4％的患者检测到病毒感染，其次是HBV（19.2％）和HCV（8.8％）。在38.6％的病例中检测到的单克隆丙种球蛋白病与EBV DNA（p = 0.002）和HCV RNA（p = 0.04）有关。 73.9％的患者发生了克隆性Ig和/或TCR基因重排。至少有一项研究参数的出现在22例患者发生恶性肿瘤之前。对于病毒感染和Ig / TCR基因重排的系统PCR分析，再加上单克隆蛋白的检测，对于在疾病的严重并发症（包括癌症）出现之前监测NBS患者具有优势。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号