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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Transmethylation in immunity and autoimmunity
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Transmethylation in immunity and autoimmunity

机译：免疫和自身免疫中的甲基转移

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The activation of immune cells is mediated by a network of signaling proteins that can undergo post-translational modifications critical for their activity. Methylation of nucleic acids or proteins can have major effects on gene expression as well as protein repertoire diversity and function. Emerging data indicate that indeed many immunologic functions, particularly those of T cells, including thymic education, differentiation and effector function are highly dependent on methylation events. The critical role of methylation in immunocyte biology is further documented by evidence that autoimmune phenomena may be curtailed by methylation inhibitors. Additionally, epigenetic alterations imprinted by methylation can also exert effects on normal and abnormal immune responses. Further work in defining methylation effects in the immune system is likely to lead to a more detailed understanding of the immune system and may point to the development of novel therapeutic approaches.
机译：免疫细胞的激活是由信号蛋白网络介导的，这些蛋白可以经历对其活性至关重要的翻译后修饰。核酸或蛋白质的甲基化可对基因表达以及蛋白质库的多样性和功能产生重大影响。新兴数据表明，确实有许多免疫功能，特别是T细胞的免疫功能，包括胸腺教育，分化和效应子功能高度依赖于甲基化事件。甲基化在免疫细胞生物学中的关键作用还通过证据证明了甲基化抑制剂可以抑制自身免疫现象。另外，由甲基化印记的表观遗传学改变也可以对正常和异常的免疫反应产生影响。定义免疫系统中甲基化作用的进一步工作可能导致对免疫系统的更详细了解，并可能指向新型治疗方法的发展。

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