Receptor tyrosine kinases: From biology to pathology

Choura M.; Reba? A.

首页> 外文期刊>Journal of receptor and signal transduction research >Receptor tyrosine kinases: From biology to pathology

【24h】

Receptor tyrosine kinases: From biology to pathology

机译：受体酪氨酸激酶：从生物学到病理学

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Receptor tyrosine kinases (RTKs) are transmembrane proteins involved in the control of fundamental cellular processes in metazoans. RTKs possess a general structure that includes an extracellular domain, a transmembrane domain and a highly conserved tyrosine kinase domain. RTKs are classified according to their variable extracellular ligand-binding domain. Studies of human RTK members have yielded a wealth of information elucidating their importance. Improper functioning of these enzymes due to mutations, mainly in the kinase domain, is often manifested in various human diseases and is known to be involved in several types of cancer. Here we summarize most of human RTKs, their cognate ligands, as well as related diseases and discuss the eventual use of certain RTKs as new therapeutic targets.

机译：受体酪氨酸激酶（RTKs）是跨膜蛋白，参与控制后生动物的基本细胞过程。 RTK具有包括细胞外结构域，跨膜结构域和高度保守的酪氨酸激酶结构域的一般结构。 RTK根据其可变的细胞外配体结合域进行分类。对人类RTK成员的研究已产生了大量信息，阐明了其重要性。这些酶由于突变（主要在激酶结构域中）引起的功能不正常，通常表现在各种人类疾病中，并且已知与多种类型的癌症有关。在这里，我们总结了大多数人类RTK，它们的同源配体以及相关疾病，并讨论了最终将某些RTK用作新的治疗靶标。

著录项

来源
《Journal of receptor and signal transduction research》 |2011年第6期|共8页
作者
Choura M.; Reba? A.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞形态学;
关键词
Disease; human; ligand; mutation; RTK;

机译：疾病;人类;配体;突变;RTK;

相似文献

外文文献
中文文献
专利

1. Receptor tyrosine kinases: From biology to pathology [J] . Choura M., Reba? A. Journal of receptor and signal transduction research . 2011,第6期

机译：受体酪氨酸激酶：从生物学到病理学
2. Molecular testing for selection of patients with lung cancer for epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine kinase inhibitors: American Society of Clinical Oncology endorsement of the college of American pathologists/international association for the study of lung cancer/association for molecular pathology guideline [J] . LeighlN.B., RekhtmanN., BiermannW.A., Journal of Clinical Oncology . 2014,第32期

机译：为肺癌患者选择表皮生长因子受体和间变性淋巴瘤激酶酪氨酸激酶抑制剂的分子测试：美国临床肿瘤学会认可的美国病理学家学院/国际肺癌研究协会/分子病理学协会联合会
3. Receptor and nonreceptor tyrosine kinases in vascular biology of hypertension. [J] . Yogi A, OConnor SE, Callera G Current opinion in nephrology and hypertension . 2010,第2期

机译：高血压血管生物学中的受体和非受体酪氨酸激酶。
4. MICROGRAVITY AND SIGNALING MOLECULES IN RAT OSTEOBLASTS: DOWNSTREAM OF RECEPTOR TYROSINE KINASE, G-PROTEIN-COUPLED RECEPTOR, AND SMALL GTP-BINDING PROTEINS [C] . Yasuhiro Kumei, Hitoyata Shimokawa, Sadao Morita, European Symposium on Life Sciences in Space . 2005

机译：大鼠成骨细胞中的微匍匐和信号分子：受体酪氨酸激酶，G蛋白偶联受体和小GTP结合蛋白的下游
5. Examining the role of redox biology in a population of neonatal cardiac precursor cells marked by the type III receptor tyrosine kinase c-kit. [D] . Nadworny, Alyson Spealman. 2012

机译：检查氧化还原生物学在以III型受体酪氨酸激酶c-kit标记的新生儿心脏前体细胞中的作用。
6. Molecular Testing for Selection of Patients With Lung Cancer for Epidermal Growth Factor Receptor and Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Guideline [O] . Natasha B. Leighl, Natasha Rekhtman, William A. Biermann, -1

机译：为表皮生长因子受体和间变性淋巴瘤激酶酪氨酸激酶抑制剂选择肺癌患者的分子检测：美国病理学家学院/国际肺癌研究协会/分子病理学协会国际临床病理学会认可
7. Molecular Testing for Selection of Patients With Lung Cancer for Epidermal Growth Factor Receptor and Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Guideline [O] . Natasha B. Leighl, Natasha Rekhtman, William A. Biermann, 2014

机译：对表皮生长因子受体和血吸虫淋巴瘤激酶酪氨酸激酶抑制剂选择肺癌患者的分子检测：美国病理学家临床肿瘤学会的认可/国际肺癌/分子病理学指南研究血阶癌症学会协会

Receptor tyrosine kinases: From biology to pathology

摘要

著录项

相似文献

相关主题

期刊订阅