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首页> 外文期刊>Journal of receptor and signal transduction research >The interplay between retinoic acid receptor-related orphan receptors and human diseases
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The interplay between retinoic acid receptor-related orphan receptors and human diseases

机译：维甲酸受体相关孤儿受体与人类疾病的相互作用

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摘要

The retinoic acid receptor-related orphan receptors (RORs) are an important subfamily of transcriptional regulators of the nuclear receptors superfamily. Their discovery over a decade ago by gene cloning strategy have revealed three major isoforms of these orphan receptors in animals. Generation and analyses of isoform-specific ROR null mice have provided revealed-vital roles for the RORs in animals. The RORs undoubtedly participate in a host of biological functions such a metabolism, immunity, development and differentiation, angiogenesis, circadian clock, xenobiotic/drug metabolism and other tissue physiologies for optimal animal survival. Moreover, intense work in the last one decade also revealed a host of human diseases being modulated by the RORs. A number of diseases, such as cancer, autoimmune diseases, inflammation, osteoporosis, metabolic syndrome etc., strongly support the involvement of RORs in their onset and progression. By involving in such diseases, the RORs are indeed a critical factor for optimal cell function and are being intensely investigated as novel targets for drug interventions in the treatment of various diseases. This review focuses on the current knowledge and status about RORs in a number of human disease conditions.
机译：视黄酸受体相关的孤儿受体（ROR）是核受体超家族的转录调节子的重要亚家族。他们在十多年前通过基因克隆策略发现了动物中这些孤儿受体的三种主要同工型。异构体特异性ROR无效小鼠的产生和分析为动物中的ROR提供了重要的作用。毫无疑问，ROR参与了许多生物学功能，例如代谢，免疫，发育和分化，血管生成，昼夜节律，异生物/药物代谢和其他组织生理，以实现最佳的动物生存。此外，最近十年来的紧张工作还揭示了许多人类疾病受到ROR的调节。许多疾病，例如癌症，自身免疫性疾病，炎症，骨质疏松症，代谢综合征等，都强烈支持ROR参与其发病和进展。通过参与此类疾病，ROR确实是实现最佳细胞功能的关键因素，并且正在被广泛研究作为治疗各种疾病的药物干预措施的新靶标。这篇综述集中在许多人类疾病条件下有关ROR的当前知识和现状。

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