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首页> 外文期刊>Journal of Reproductive Immunology >Acute systemic immune activation following vaginal exposure to staphylococcal enterotoxin B--implications for menstrual shock.
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Acute systemic immune activation following vaginal exposure to staphylococcal enterotoxin B--implications for menstrual shock.

机译：阴道接触葡萄球菌肠毒素B后的急性全身免疫激活-对月经休克的影响。

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Menstrual toxic shock syndrome (mTSS) is an acute systemic inflammatory disease associated with the superantigenic exotoxin, toxic shock syndrome toxin (TSST)-1, produced by Staphylococcus aureus and the use of high absorbency tampons. Even though S. aureus is capable of elaborating several other superantigenic exotoxins, only TSST-1 has been implicated in the pathogenesis of mTSS possibly because most other superantigenic exotoxins are known enterotoxins. Nonetheless, we have shown recently that one of the enterotoxigenic staphylococcal superantigens, staphylococcal enterotoxin B (SEB), can cause robust systemic immune activation following exposure through non-enteric mucosa, including nasal or conjunctival routes. In a similar manner, we show here that vaginal administration of SEB in HLA class II transgenic mice can cause robust systemic immune activation characterized by profound elevation of proinflammatory cytokines in the serum, activation and expansion of SEB-reactive CD4(+) and CD8(+) T cells in peripheral lymphoid organs and SEB-induced deletion of immature thymocytes. Vaginal administration of SEB also caused leukocytic infiltration in major organs, such as liver and lung, reminiscent of human toxic shock syndrome. Systemic immune activation following vaginal superantigen delivery was independent of the stage of the estrus cycle in the mouse. Using HLA class II transgenic mice, we have shown that exposure to SEB through the vaginal canal can cause robust systemic immune activation. SEB could thus play a role in the pathogenesis of mTSS.
机译：月经中毒性休克综合征（mTSS）是一种急性系统性炎症，与金黄色葡萄球菌产生的超抗原外毒素，中毒性休克综合征毒素（TSST）-1和高吸收性棉塞的使用有关。即使金黄色葡萄球菌能够修饰其他几种超抗原外毒素，也只有TSST-1参与了mTSS的发病机制，这可能是因为大多数其他超抗原外毒素是已知的肠毒素。尽管如此，我们最近显示，一种产肠毒素的葡萄球菌超抗原之一，葡萄球菌肠毒素B（SEB）在通过非肠胃粘膜（包括鼻腔或结膜途径）暴露后，可以引起强大的全身免疫激活。以类似的方式，我们在这里显示，在HLA II类转基因小鼠中阴道施用SEB可以引起强大的全身免疫激活，其特征在于血清中促炎细胞因子的显着升高，SEB反应性CD4（+）和CD8（的激活和扩展） +）外周淋巴器官中的T细胞和SEB诱导的未成熟胸腺细胞的缺失。阴道SEB给药还引起肝，肺等主要器官的白细胞浸润，让人联想到人类毒性休克综合症。阴道超抗原递送后的全身免疫激活与小鼠发情周期的阶段无关。使用HLA II类转基因小鼠，我们已经表明，通过阴道管暴露于SEB可以引起强大的全身性免疫激活。 SEB因此可以在mTSS的发病机理中起作用。

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