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首页> 外文期刊>Journal of Reproductive Immunology >Zona pellucida-based contraceptive vaccines for human and animal utility.
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Zona pellucida-based contraceptive vaccines for human and animal utility.

机译：基于Zona pellucida的避孕药，可用于人类和动物。

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摘要

Contraceptive vaccines can be designed to inhibit (i) production of the gametes (sperm and oocyte), (ii) functions of gametes leading to block in fertilization, and (iii) the gamete outcome (pregnancy). The zona pellucida (ZP) glycoproteins have been proposed as candidates for developing contraceptive vaccines by virtue of their critical role in fertilization. Immunization of non-human primates with either native or recombinant ZP proteins leads to curtailment of fertility, which however is invariably associated with ovarian pathology. To avoid oophoritis, immunogens corresponding to mapped B cell epitopes of ZP proteins that are devoid of 'oophoritogenic' T cell epitopes have been proposed. However, ways to overcome the observed oophoritis associated with the ZP-based contraceptive vaccines are yet to be fully defined. This is essential if their use for control of human fertility is to be considered. Nonetheless, contraceptive vaccines based on ZP proteins have shown very promising results in controlling wildlife population such as wild horses, white-tailed deers, elephants, marsupials, grey seals and dogs, where long term infertility or even permanent sterility is desirable.
机译：可将避孕药设计为抑制（i）配子（精子和卵母细胞）的产生，（ii）导致受精受阻的配子功能，以及（iii）配子结局（怀孕）。透明带（ZP）糖蛋白因其在受精中的关键作用而被提议作为开发避孕疫苗的候选者。用天然或重组ZP蛋白免疫非人灵长类动物会导致生育能力下降，但是这总是与卵巢病理有关。为了避免卵泡炎，已经提出了与ZP蛋白的映射的B细胞表位相对应的免疫原，其没有“卵原性” T细胞表位。然而，克服与基于ZP的避孕疫苗相关的卵巢炎的方法尚未完全确定。如果要考虑将其用于控制​​人类生育力，这是至关重要的。尽管如此，基于ZP蛋白的避孕疫苗在控制野生生物种群方面显示出非常有希望的结果，例如野马，白尾鹿，大象，有袋动物，灰海豹和狗，这些地方需要长期不育甚至永久不育。

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