...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Reproductive Immunology >A retrospective study on IVF outcome in patients with anticardiolipin antibody: Effects of methylprednisolone plus low-dose aspirin adjuvant treatment
【24h】

A retrospective study on IVF outcome in patients with anticardiolipin antibody: Effects of methylprednisolone plus low-dose aspirin adjuvant treatment

机译：抗心磷脂抗体患者IVF结局的回顾性研究：甲基强的松龙加小剂量阿司匹林辅助治疗的效果

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Patients undergoing in vitro fertilization-embryo transfer have a high prevalence of anticardiolipin antibody (ACA). However, the relationship between ACA and IVF outcome is still controversial. The aim of the present study was to evaluate the potential effect of anticardiolipin antibody on IVF outcome and determine the role of adjuvant treatment in these ACA positive patients. The study included a total of 116 infertile women (116 IVF-ET cycles) positive for ACA, including 56 women pretreated with methylprednisolone plus low-dose aspirin before IVF (treated ACA+ group) and 60 patients without treatment (untreated ACA+ group). In addition, 518 infertile women (518 IVF-ET cycles) negative for ACA were enroled as controls (ACA- group). The results show that ACA+ patients who did not receive any adjuvant treatment showed a significantly lower fertilization rate, less high-quality embryos, as well as a markedly lower pregnancy rate and implantation rate than controls. Moreover, ACA+ patients who received methylprednisolone plus aspirin achieved significantly higher fertilization, pregnancy and implantation rates than untreated ACA+ patients (FR 69.0%, PR 46.4% and IR 25.4% vs. FR 60.0%, PR 33.3% and IR 17.9%, respectively). The overall IVF results in the treated ACA+ group were comparable to patients negative for ACA (PR 53.9% and IR 32.3%). Thus, while the presence of ACA exerts a detrimental effect on IVF outcome, ACA+ patients have a better outcome if given methylprednisolone for immunosuppression and low-dose aspirin as an anti-thrombotic agent.
机译：进行体外受精-胚胎移植的患者抗心磷脂抗体（ACA）的患病率很高。但是，ACA和IVF结果之间的关系仍存在争议。本研究的目的是评估抗心磷脂抗体对IVF结果的潜在影响，并确定在这些ACA阳性患者中辅助治疗的作用。该研究共纳入116名ACA阳性的不育妇女（116个IVF-ET周期），包括56名在IVF之前接受甲基泼尼松龙加小剂量阿司匹林治疗的妇女（ACA +治疗组）和60名未经治疗的妇女（未经治疗的ACA +组）。此外，将518名ACA阴性的不育女性（518个IVF-ET周期）作为对照（ACA-组）。结果表明，未接受任何辅助治疗的ACA +患者显示出受精率明显低于对照组，优质胚胎较少，而且妊娠率和着床率也明显低于对照组。此外，接受甲基强的松龙加阿司匹林的ACA +患者的受精，妊娠和着床率明显高于未经治疗的ACA +患者（FR 69.0％，PR 46.4％和IR 25.4％相对于FR 60.0％，PR 33.3％和IR 17.9％） 。经治疗的ACA +组的总体IVF结果与ACA阴性的患者相当（PR 53.9％和IR 32.3％）。因此，虽然ACA的存在对IVF结局有不利影响，但如果给予甲基泼尼松龙进行免疫抑制和小剂量阿司匹林作为抗血栓形成剂，ACA +患者的结局会更好。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号