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首页> 外文期刊>Journal of Reproductive Immunology >Acetaminophen and pregnancy: Short- and long-term consequences for mother and child
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Acetaminophen and pregnancy: Short- and long-term consequences for mother and child

机译：对乙酰氨基酚和怀孕：对母婴的短期和长期后果

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Counter-intuitively, over-the-counter medication is commonly taken by pregnant women. In this context, acetaminophen (APAP, e.g. Paracetamol, Tylenol) is generally recommended by physicians to treat fever and pain during pregnancy. Thus, APAP ranks at the top of the list of medications taken prenatally. Insights on an increased risk for pregnancy complications such as miscarriage, stillbirth, preterm birth or fetal malformations upon APAP exposure are rather ambiguous. However, emerging evidence arising from human trials clearly reveals a significant correlation between APAP use during pregnancy and an increased risk for the development of asthma in children later in life. Pathways through which APAP increases this risk are still elusive. APAP can be liver toxic and since APAP appears to freely cross the placenta, therapeutic and certainly toxic doses could not only affect maternal, but also fetal hepatocytes. It is noteworthy that during fetal development, the liver transiently functions as the main hematopoietic organ. We here review the effect of APAP on metabolic and immunological parameters in pregnant women and on fetal development and immune ontogeny in order to delineate novel, putative and to date underrated pathways through which APAP use during pregnancy can impair maternal, fetal and long term children's health. We conclude that future studies are urgently needed to reconsider the safety and dosage of APAP during pregnancy and - based on the advances made in the field of reproduction as well as APAP metabolism - we propose pathways, which should be addressed in future research and clinical endeavors. ? 2012 Elsevier Ireland Ltd.
机译：与直觉相反，孕妇通常服用非处方药。在这种情况下，医师通常推荐使用对乙酰氨基酚（APAP，例如扑热息痛，泰诺）来治疗妊娠期间的发烧和疼痛。因此，APAP在产前服用的药物列表中排名第一。暴露于APAP后怀孕流产，死产，早产或胎儿畸形等妊娠并发症风险增加的见解还很模糊。然而，来自人体试验的新证据清楚地表明，怀孕期间使用APAP与以后生命中儿童患哮喘的风险增加之间存在显着相关性。 APAP增加这种风险的途径仍然难以捉摸。 APAP可能对肝脏有毒性，并且由于APAP似乎可以自由穿过胎盘，因此治疗剂量和肯定有毒的剂量不仅会影响母体，还可能影响胎儿的肝细胞。值得注意的是，在胎儿发育期间，肝脏短暂地充当主要的造血器官。我们在这里回顾APAP对孕妇的代谢和免疫学参数以及胎儿发育和免疫个体发育的影响，以便描述在怀孕期间使用APAP可能损害孕产妇，胎儿和长期儿童健康的新颖，推定和迄今为止被低估的途径。 。我们得出结论，迫切需要未来的研究来重新考虑怀孕期间APAP的安全性和剂量，并且-根据生殖和APAP代谢领域的进展-我们提出了一些途径，这些途径应在未来的研究和临床研究中加以解决。 ？ 2012爱思唯尔爱尔兰有限公司

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