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首页> 外文期刊>Journal of Reproductive Immunology >The potential use of sperm antigens as targets for immunocontraception; past, present and future.
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The potential use of sperm antigens as targets for immunocontraception; past, present and future.

机译：精子抗原作为免疫避孕靶标的潜在用途;过去，现在和未来。

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Immunocontraception, and in particular the targeting of antibodies to gamete-specific antigens implicated in sperm egg binding and fertilisation, offers an attractive approach to the growing global problem of overpopulation. Such an idea is not new; indeed several immunocontraception trials, using animal model systems, have been reported in recent years and a number are reviewed here. However, the results of these studies have been largely disappointing. We believe that two fundamental flaws attribute to the poor success of most of these preliminary immunocontraceptive trials. Firstly, loss of fertility has invariably been used as the assay. This presupposes that immuno-neutralisation of a single, gamete-specific antigen will be sufficient to cause a significant reduction in fertility; however, recent data suggests that such a premise may not be well-founded for a number of reasons. Secondly, and arguably the most important flaw, is the almost universal, but largely inappropriate, use of systemic immunisation as the sole route of antigen delivery. Whilst systemic immunisation regimes may lead to high serum IgG levels, these levels do not correlate with specific antibody levels in the reproductive tract or with contraceptive efficacy. Hence, an alternative antigen delivery approach is required which will induce an effective local immune response in the reproductive tract. Here we discuss the ways in which this might be achieved.
机译：免疫避孕，尤其是将抗体靶向与精子卵结合和受精有关的配子特异性抗原，为日益增长的全球人口过剩问题提供了一种有吸引力的方法。这样的想法并不新鲜。的确，近年来已经报道了使用动物模型系统进行的几种免疫避孕试验，这里有许多综述。但是，这些研究的结果在很大程度上令人失望。我们认为，两个基本的缺陷归因于大多数这些初步的免疫避孕试验的成功。首先，育性丧失总是被用作分析方法。前提是单个配子特异性抗原的免疫中和作用足以引起生育力的显着降低。但是，最近的数据表明，由于多种原因，这种前提可能没有充分根据。其次，可以说，最重要的缺陷是将全身免疫作为抗原递送的唯一途径，这几乎是普遍的，但在很大程度上是不合适的。尽管全身免疫方案可能导致血清IgG高水平，但这些水平与生殖道中的特定抗体水平或避孕功效无关。因此，需要替代的抗原递送方法，其将在生殖道中诱导有效的局部免疫应答。在这里，我们讨论了实现此目标的方法。

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