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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus
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Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

机译：瘦素相关多态性与系统性红斑狼疮的遗传关联

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Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE. (C) 2015 Elsevier Inc. All rights reserved.
机译：系统性红斑狼疮（SLE）患者血浆中的瘦素异常升高，据认为可促进和/或维持促炎反应。目前尚不清楚这种关联是否可以反映出发展为SLE的遗传易感性增加，迄今为止对SLE患者中与瘦素相关多态性的遗传关联的研究尚无定论。在这里，我们对15706名SLE患者和来自四个祖先的健康匹配对照的DNA样本进行了基因分型，以将瘦素途径基因的多态性与SLE风险相关联。结果发现，尽管几个SNP显示弱关联，但在进行多次测试校正后，这些关联仍然不显着。这些数据不支持定义的瘦素相关多态性与发展SLE的易感性之间的关联。 （C）2015 Elsevier Inc.保留所有权利。

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