• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Breast regression protein-39 is not required for experimental autoimmune encephalomyelitis induction
【24h】

Breast regression protein-39 is not required for experimental autoimmune encephalomyelitis induction

机译：实验性自身免疫性脑脊髓炎的诱导不需要乳房消退蛋白39

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Increasing evidence points to a role for chitinase 3-like 1 (CHI3L1) in multiple sclerosis (MS). Here, we aimed to explore the potential involvement of CHI3L1 in the animal model of MS, experimental autoimmune encephalomyelitis (EAE). EAE was induced by immunization with MOG(35-55) peptide in wild-type (WT) and knock-out (KO) mice for breast regression protein 39 (BRP-39), the mouse homologue of human CHI3L1. Immunological responses in splenocytes were assessed by means of polyclonal and antigen-specific proliferation assays. Central nervous system. pathology and chitinase gene expression were also investigated. BRP-39 expression was increased in WT MOG(35-55)-immunized mice compared to saline-immunized controls. No differences were found between WT and BRP-39 KO mice regarding EAE clinical course, day of disease onset, mortality rate, splenocyte proliferative responses or histopathological findings. These results do not support a role of BRP-39 in the pathogenesis of EAE. (C) 2015 Elsevier Inc. All rights reserved.
机译：越来越多的证据表明几丁质酶3样1（CHI3L1）在多发性硬化症（MS）中的作用。在这里，我们旨在探讨CHI3L1在MS动物模型中的作用，即实验性自身免疫性脑脊髓炎（EAE）。通过在野生型（WT）和基因敲除（KO）小鼠中用MOG（35-55）肽免疫接种人乳腺回归蛋白39（BRP-39）（人CHI3L1的小鼠同源物）来诱导EAE。通过多克隆和抗原特异性增殖测定法评估脾细胞中的免疫反应。中枢神经系统。还研究了病理学和几丁质酶基因表达。与盐水免疫对照组相比，WT MOG（35-55）免疫小鼠中BRP-39表达增加。 WT和BRP-39 KO小鼠在EAE临床病程，发病日期，死亡率，脾细胞增殖反应或组织病理学发现方面无差异。这些结果不支持BRP-39在EAE发病机理中的作用。 （C）2015 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号