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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >The recipient CXCL10 +1642C>G variation predicts survival outcomes after HLA fully matched unrelated bone marrow transplantation
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The recipient CXCL10 +1642C>G variation predicts survival outcomes after HLA fully matched unrelated bone marrow transplantation

机译：接受者CXCL10 + 1642C> G变异预测HLA完全匹配无关骨髓移植后的生存结果

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摘要

CXCL10 is a chemoattractant for immune cells that is involved in several immune-inflammatory disorders. This study retrospectively examined the impact of a single nucleotide variation (rs3921, +. 1642C>G) in the CXCL10 gene on transplant outcomes in a cohort of 652 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. The recipient C/G or G/G genotype was found to be associated with a significantly better 5-year overall survival (OS) rate and a lower transplant-related mortality (TRM) rate than the recipient C/C genotype. The recipient C/G or G/G genotype also predicted a reduced incidence of death due to organ failure. The multivariate analysis showed the recipient C/G or G/G genotype to exhibit statistical trends toward beneficial effects on OS but not on TRM. CXCL10 genotyping could therefore be useful in predicting prognoses and creating therapeutic strategies for improving the final outcomes of patients who undergo allogeneic BMT. ? 2012 Elsevier Inc.
机译：CXCL10是免疫细胞的趋化因子，参与多种免疫炎症性疾病。这项研究回顾性研究了652例接受不相关HLA匹配骨髓移植（BMT）血液系统恶性肿瘤患者的队列研究，结果表明CXCL10基因中单个核苷酸变异（rs3921，+。1642C> G）对移植结局的影响。发现接受者C / G或G / G基因型与接受者C / C基因型相比具有显着更好的5年总生存率（OS）和较低的移植相关死亡率（TRM）率。接受者的C / G或G / G基因型还预测了由于器官衰竭而导致死亡的减少。多变量分析表明，接受者的C / G或G / G基因型表现出对OS有益但对TRM无益的统计学趋势。因此，CXCL10基因分型可用于预测预后并创建治疗策略，以改善接受异基因BMT的患者的最终结局。 ？ 2012爱思唯尔公司

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