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首页> 外文期刊>Journal of refractive surgery >Cleaning solutions as a cause of diffuse lamellar keratitis.
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Cleaning solutions as a cause of diffuse lamellar keratitis.

机译：清洁溶液可导致弥漫性片状角膜炎。

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PURPOSE: To assess the capability of two microkeratome cleaning solutions in causing diffuse lamellar keratitis (DLK) in a rabbit model of laser in situ keratomileusis (LASIK). METHODS: Two cleaning solutions (Palmolive 2:100 and Cidezyme 2:250) were tested. These solutions were diluted with balanced salt solution according to directions from the Hansatome microkeratome manual. Two additional solutions were prepared using an additional ten-fold dilution, creating a total of four study solutions. A LASIK flap was created in one eye each of 25 rabbits using the ALK Chiron microkeratome. The rabbits were divided into five study groups. The flaps were reflected and a drop of one of the study solutions (or BSS, control group) was placed on the interface. After 1 minute, the solution was washed out from the interface and the flap was repositioned. The eyes were examined at the slit lamp on postoperative days 1, 2, 3, 5, and 7. RESULTS: In 12 eyes, a flap displacement was identified. Four eyes showed flap retraction and five others, epithelial ingrowth in flap margins. The incidence of these events did not differ among groups. Thirteen eyes were then evaluated for DLK. No DLK-like interface inflammation was seen in the studied eyes. CONCLUSION: The cleaning solutions, when diluted as recommended by the microkeratome manufacturer, when in contact with the corneal stroma, and provided that the interface was washed with BSS did not cause DLK interface inflammation in rabbit LASIK models.
机译：目的：在兔激光原位角膜磨镶术（LASIK）模型中评估两种微角膜刀清洁溶液引起弥漫性层状角膜炎（DLK）的能力。方法：测试了两种清洁溶液（Palmolive 2：100和Cidezyme 2：250）。根据Hansatome microkeratome手册的指示，用平衡盐溶液稀释这些溶液。使用另外的十倍稀释液制备了另外两种溶液，总共产生了四种研究溶液。使用ALK Chiron微型角膜刀在每只25只兔子的一只眼睛中制作一个LASIK皮瓣。将兔子分成五个研究组。拍打皮瓣，将一滴研究溶液（或BSS，对照组）放在界面上。 1分钟后，将溶液从界面上冲洗掉，并重新放置挡板。术后第1、2、3、5和7天在裂隙灯处检查眼睛。结果：在12只眼中，发现了皮瓣移位。四只眼显示皮瓣缩回，另外五只眼显示皮瓣边缘上皮向内生长。这些事件的发生率在各组之间没有差异。然后评估十三只眼的DLK。在研究的眼睛中未观察到DLK样界面炎症。结论：按照微型角膜刀制造商的建议稀释的清洁溶液，当与角膜基质接触时，并假设用BSS冲洗界面不会在兔LASIK模型中引起DLK界面发炎。

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