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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Macrophage Fcgamma receptors expression is altered by treatment with dopaminergic drugs.
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Macrophage Fcgamma receptors expression is altered by treatment with dopaminergic drugs.

机译：巨噬细胞Fcγ受体的表达通过多巴胺能药物治疗而改变。

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Macrophage Fcgamma receptors have an important role in host defense and the pathophysiology of immune mediated disorders. Alteration of splenic macrophage Fcgamma receptors expression predisposes to severe infection. Inhibition or blockade of splenic macrophage Fcgamma receptors is one of the mechanisms by which immune cytopenias improve. Dopaminergic drugs have clinically significant regulatory functions on the immune response. Using an experimental model in the guinea pig we assessed the effect of commonly used dopaminergic drugs on the expression of macrophage Fcgamma receptors. Three dopa-antagonists, bromocryptine, leuprolide, and pergolide, and seven dopa-antagonists, chlorpromazine, SCH 23390, metochlopramide, sulpiride, veralipride, alizapride, and cisapride, were studied. Following guinea pig treatment with dopaminergic drugs, the clearance of IgG-sensitized RBCs in vivo, the in vitro binding of IgG-sensitized RBCs by isolated splenic macrophages and flow cytometry with monoclonal antibodies were performed. Treatment with dopa-agonists enhanced the clearance of IgG-sensitized RBCs, the in vitro binding of IgG-sensitized RBCs by isolated splenic macrophages, and the cell surface expression of both macrophage Fcgamma receptors, and vice versa, dopa-antagonists impaired macrophage Fcgamma receptors expression. Macrophage FcgammaR1,2 was more sensitive than FcgammaR2 to such dopaminergic effect. These alterations of macrophage Fcgamma receptors expression are mediated by both D1 and D2 dopamine receptors, with a major participation of D2 receptors. Dopaminergic drugs alter the clearance of IgG-coated cells by an effect at the expression of splenic macrophage Fcgamma receptors. Copyright 1999 Academic Press.
机译：巨噬细胞Fcγ受体在宿主防御和免疫介导的疾病的病理生理中起重要作用。脾脏巨噬细胞Fcγ受体表达的改变容易导致严重感染。脾脏巨噬细胞Fcγ受体的抑制或阻断是免疫性血细胞减少的机制之一。多巴胺能药物对免疫反应具有临床上重要的调节功能。使用豚鼠的实验模型，我们评估了常用的多巴胺能药物对巨噬细胞Fcγ受体表达的影响。研究了3种多巴拮抗剂，溴隐汀，亮丙瑞林和培高利特，以及7种多巴拮抗剂，氯丙嗪，SCH 23390，甲氨蝶呤，舒必利，维拉利普利，阿利沙必利和西沙必利。用多巴胺能药物治疗豚鼠后，体内清除了IgG致敏的RBC，通过分离的脾巨噬细胞对IgG致敏的RBC进行了体外结合，并用单克隆抗体进行了流式细胞术。多巴受体激动剂的治疗增强了IgG敏感的RBC的清除，离体脾脏巨噬细胞对IgG敏感的RBC的体外结合以及两种巨噬细胞Fcgamma受体的细胞表面表达，反之亦然，多巴拮抗剂会损害巨噬细胞Fcgamma受体表达。巨噬细胞FcγR1，2比FcγR2对这种多巴胺能作用更敏感。巨噬细胞Fcγ受体表达的这些改变是由D1和D2多巴胺受体介导的，其中D2受体的主要参与。多巴胺能药物通过影响脾脏巨噬细胞Fcgamma受体的表达来改变IgG包被细胞的清除。版权所有1999，学术出版社。

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