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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Distribution of IgM and IgG antibodies to oxidized LDL in immune complexes isolated from patients with type 1 diabetes and its relationship with nephropathy.
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Distribution of IgM and IgG antibodies to oxidized LDL in immune complexes isolated from patients with type 1 diabetes and its relationship with nephropathy.

机译：从1型糖尿病患者分离的免疫复合物中IgM和IgG抗体对氧化LDL的分布及其与肾病的关系。

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摘要

Modified lipoproteins are immunogenic and play a key pathogenic role in vascular disease. Antibodies to oxidized LDL (oxLDL) are mostly of the pro-inflammatory IgG1 and IgG3 isotypes. We measured IgG and IgM oxLDL antibodies in immune complexes (IC) isolated from 36 patients with type 1 diabetes using a nested case control design. IgG antibodies predominated over IgM antibodies by an 8:1 ratio. IgG antibody concentrations were higher in the nephropathy cases compared to controls (p = 0.09), but no significant difference was observed because of two patients included in the study who had end-stage renal disease (creatinine 5 mg/dL and glomerular filtration rate (GFR) less than 17 mL/min). After eliminating these patients from the analysis, significant positive associations of IgG antibody concentration with serum creatinine and albumin excretion rate were observed. Similarly, a negative correlation with estimated glomerular filtration rate was observed in this subsample of 34 patients. Differences in IgM antibody concentrations by nephropathy classification were not supported by the data. In conclusion, the predominance of pro-inflammatory IgG oxLDL antibodies is associated with existence of diabetic nephropathy, and a protective role of IgM antibodies could not be demonstrated.
机译：修饰的脂蛋白具有免疫原性，在血管疾病中起关键的致病作用。氧化的LDL（oxLDL）抗体大多是促炎性IgG1和IgG3同种型。我们使用巢式病例对照设计测量了从36例1型糖尿病患者中分离出的免疫复合物（IC）中的IgG和IgM oxLDL抗体。 IgG抗体比IgM抗体占8​​：1的比例。肾病患者的IgG抗体浓度高于对照组（p = 0.09），但未观察到显着差异，因为该研究中包括两名患有终末期肾脏疾病的患者（肌酐> 5 mg / dL和肾小球滤过率（GFR）低于17毫升/分钟）。从分析中剔除这些患者后，观察到IgG抗体浓度与血清肌酐和白蛋白排泄率显着正相关。同样，在该34位患者的子样本中，观察到与估计的肾小球滤过率呈负相关。数据不支持通过肾病分类得出的IgM抗体浓度差异。总之，促炎性IgG oxLDL抗体的优势与糖尿病性肾病的存在有关，无法证明IgM抗体的保护作用。

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