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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells.
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Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells.

机译：TSLP受体的局部阻滞通过调节气道树突状细胞减轻了过敏性疾病。

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摘要

Thymic stromal lymphopoietin (TSLP) emerges as a central mediator of T helper cell (Th)2-dominant allergic diseases. However, the role of TSLP receptor (TSLPR) in allergen-induced Th2 priming, and the effects of TSLP signaling blocking on the development of asthma remain unclear. Here we showed that allergen challenge caused a rapid accumulation of TSLP in the airways of asthmatic mice, correlating well with eosinophils counts and interleukin (IL)-5 productions. When TSLP signaling was blocked by intratracheal administration of anti-TSLPR antibody before sensitization, eosinophilic airway inflammation, goblet cell hyperplasia and Th2 cytokines productions were significantly reduced. The alleviating effects of TSLPR blocking were achieved by inhibition of maturation and migration of airway dendritic cells (DCs), as well as their abilities of initiating CD4+T cell responses. Thus, local application of anti-TSLPR prevented Th2-mediated airway inflammation, at least partly, by regulating DCs function, which might be exploited to develop novel treatments for asthma.
机译：胸腺基质淋巴细胞生成素（TSLP）成为T辅助细胞（Th）2占主导地位的过敏性疾病的主要介质。然而，尚不清楚TSLP受体（TSLPR）在变应原诱导的Th2引发中的作用以及TSLP信号传导阻断对哮喘发展的影响。在这里，我们显示过敏原激发导致哮喘小鼠气道中TSLP迅速积累，与嗜酸性粒细胞计数和白介素（IL）-5产生密切相关。当在致敏前通过气管内施用抗TSLPR抗体阻断TSLP信号传导时，嗜酸性气道炎症，杯状细胞增生和Th2细胞因子的产生显着降低。通过抑制气道树突状细胞（DC）的成熟和迁移以及它们启动CD4 + T细胞应答的能力，可以达到TSLPR阻断的缓解作用。因此，抗TSLPR的局部应用至少部分地通过调节DC的功能来预防Th2介导的气道炎症，这可被用于开发哮喘的新疗法。

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