• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Demonstration of autoantibody binding to muscarinic acetylcholine receptors in the salivary gland in primary Sjogren's syndrome.
【24h】

Demonstration of autoantibody binding to muscarinic acetylcholine receptors in the salivary gland in primary Sjogren's syndrome.

机译：在原发性干燥综合征中，证明自身抗体与唾液腺中毒蕈碱型乙酰胆碱受体结合。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A significant pathogenetic role of antimuscarinic acetylcholine receptor-3 (anti-m3AChR) autoantibodies in primary Sjogren's syndrome (pSS) has been suggested. However, the binding of these antibodies to the receptors in the target tissues has not yet been demonstrated. In this study, the binding characteristics of pSS sera and anti-m3AChR-monospecific sera affinity-purified from pSS patients to labial salivary gland samples from healthy subjects were studied with light- and electron microscopy. Furthermore, the ultrastructural localisation of in vivo deposited antibodies in pSS salivary glands was also investigated. Light microscopic immunohistochemistry revealed the binding of the anti-m3AChR-specific sera to the membrane of acinar cells. Similar reaction end-products were observed in the pSS salivary gland epithelial cell membranes. With electron microscopy, the autoantibody binding was observed to be localised to the junctions of epithelial cell membranes with nerve endings, both in normal and pSS glands. The results indicate that anti-m3AChR antibodies bind to the receptors in the salivary glands.
机译：有人提出抗毒蕈碱型乙酰胆碱受体3（anti-m3AChR）自身抗体在原发性干燥综合征（pSS）中具有重要的致病作用。然而，尚未证明这些抗体与靶组织中的受体的结合。在这项研究中，通过光学和电子显微镜研究了从pSS患者中亲和纯化的pSS血清和抗m3AChR单特异性血清与健康受试者的唾液腺样品的结合特性。此外，还研究了体内沉积的抗体在pSS唾液腺中的超微结构定位。光学显微免疫组织化学显示抗m3AChR特异性血清结合到腺泡细胞膜上。在pSS唾液腺上皮细胞膜中观察到了相似的反应终产物。用电子显微镜观察到，在正常腺体和pSS腺体中，自身抗体结合都定位于具有神经末梢的上皮细胞膜的连接处。结果表明，抗m3AChR抗体与唾液腺中的受体结合。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号