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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >A physiological role for inducible FOXP3(+) Treg cells. Lessons from women with reproductive failure.
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A physiological role for inducible FOXP3(+) Treg cells. Lessons from women with reproductive failure.

机译：诱导型FOXP3（+）Treg细胞的生理作用。生殖衰竭妇女的经验教训。

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We have previously shown a decreased frequency and function of Tregs in women suffering from recurrent spontaneous abortions (RSA). In the current study, we first investigated the expression of FOXP3 after T-cell activation. We observed that expression of FOXP3 in activated PBMCs was already present above baseline before any cell division, indicating that it was induced in cells that were previously negative for this transcription factor. Because RSA women showed a more limited expansion of FOXP3-positive cells, we next assessed the role of IL-2 signaling through STAT5, which is known to be required for generation of inducible Tregs (iTregs). We demonstrated not only that TGF-beta and IL-2 were diminished but also that the IL-2-STAT-5 signaling axis was down regulated in RSA women. Finally, in addition to a limited FOXP3(+) cells expansion in vitro, iTregs from RSA women showed a strikingly lower suppressor activity.
机译：我们先前显示患有反复自然流产（RSA）的女性中Treg的频率和功能降低。在当前的研究中，我们首先研究了T细胞活化后FOXP3的表达。我们观察到在任何细胞分裂之前，FOXP3在活化的PBMC中的表达已经高于基线，这表明它是在先前对该转录因子阴性的细胞中诱导的。因为RSA妇女显示出FOXP3阳性细胞的扩增更为有限，所以我们接下来评估了通过STAT5产生IL-2信号的作用，已知这是产生诱导型Treg（iTreg）所必需的。我们不仅证明了TGF-β和IL-2降低了，而且IL-2-STAT-5信号轴在RSA妇女中被下调。最后，除了在体外有限的FOXP3（+）细胞扩增外，来自RSA女性的iTregs还显示出显着较低的抑制活性。

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