• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Immunostimulatory sequence oligodeoxynucleotide: A novel mucosal adjuvant.
【24h】

Immunostimulatory sequence oligodeoxynucleotide: A novel mucosal adjuvant.

机译：免疫刺激序列寡聚脱氧核苷酸：一种新型的粘膜佐剂。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The majority of infectious agents enter the body via mucosal surfaces. Therefore, there is great interest in developing vaccination strategies that lead to mucosal immunity. However, to generate strong mucosal immune responses to nonreplicating immunogens, mucosal delivery with an adjuvant is required, and no safe and effective mucosal adjuvants are presently available for use in humans. Recently, immunostimulatory sequence oligodeoxynucleotide (ISS-ODN) has been shown to be a potent mucosal adjuvant. Intranasal (i.n.) delivery of antigen with ISS-ODN elicits a secretory IgA response both locally in respiratory secretions and distally in intestinal and vaginal secretions. In this regard, ISS-ODN has been shown to be as effective as cholera toxin (CT), but unlike CT, ISS-ODN has not been shown to have significant toxicity. Furthermore, i.n. antigen/ISS-ODN coimmunization induces a strong Th(1)-biased systemic immune response with cytotoxic T lymphocyte activity. These observations suggest that ISS-ODN would be an ideal mucosal adjuvant for development of vaccines against mucosal pathogens. Copyright 2000 Academic Press.
机译：大多数传染原通过粘膜表面进入人体。因此，对开发导致粘膜免疫的疫苗接种策略非常感兴趣。然而，为了产生对非复制性免疫原的强粘膜免疫应答，需要用佐剂进行粘膜递送，并且目前尚无可用于人类的安全有效的粘膜佐剂。最近，免疫刺激序列寡聚脱氧核苷酸（ISS-ODN）已被证明是有效的粘膜佐剂。用ISS-ODN鼻内（i.n.）递送抗原会在呼吸道分泌物局部以及肠道和阴道分泌物的远端引起分泌性IgA反应。在这方面，已证明ISS-ODN与霍乱毒素（CT）一样有效，但与CT不同，尚未证明ISS-ODN具有明显的毒性。此外，抗原/ ISS-ODN共免疫可诱导强烈的Th（1）偏向的全身免疫反应，并具有细胞毒性T淋巴细胞活性。这些观察结果表明，ISS-ODN将是开发针对粘膜病原体的疫苗的理想粘膜佐剂。版权所有2000学术出版社。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号