• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27~IgM~(high) B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation
【24h】

A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27~IgM~(high) B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation

机译：糖基化依赖的CD45RB表位定义了以前未确认的CD27〜IgM〜（高）B细胞亚群，这些亚群在幼儿中和造血干细胞移植后富集

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract The immune system is dysfunctional for years after hematopoietic stem cell transplantation (HSCT). A potential cause is an intrinsic B cell deficiency. In a cohort of pediatric HSCT patients few CD27~+ B cells formed after transplantation with the number of CD27~+IgM~(high) cells more affected than class-switched ones. A previously unacknowledged population of CD27 lgM~(high) cells made up the majority of B cells and this population was also enlarged in healthy children compared to adults. Only a minority of these CD271gM~(high) B cells expressed markers typical for transitional B cells, and the non-transitional CD27~-lgM~(high) cells could be further divided into subpopulations based on their ability to extrude the dye Rhodamine 123 and their expression of CD45RB~(MEM55), a glycosylation-dependent epitope. Thus, we define several novel human CD27 lgM~(high) B cell subpopulations in blood, all of which are present in higher frequencies and numbers in young children and after HSCT than in adults.
机译：摘要造血干细胞移植（HSCT）后，免疫系统功能失调已有多年。潜在原因是内在的B细胞缺乏。在一批小儿HSCT患者中，移植后几乎没有形成CD27〜+ B细胞，而CD27〜+ IgM〜（high）细胞的数量比类转换细胞受到的影响更大。以前未被承认的CD27 lgM〜（高）细胞群构成了大多数B细胞，并且与成人相比，健康儿童的这一群也有所增加。这些CD271gM〜（高）B细胞中只有少数表达过渡B细胞的典型标志物，非过渡CD27〜-lgM〜（高）细胞可根据其挤出染料若丹明123的能力进一步分为亚群。及其糖基化依赖性表位CD45RB〜（MEM55）的表达。因此，我们在血液中定义了几种新型的人类CD27 lgM〜（高）B细胞亚群，它们在成人和HSCT之后的频率和数量均比成人高。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号